Comparison in the biological characteristics between primary cultured sensory and motor Schwann cells
Comparison in the biological characteristics between primary cultured sensory and motor Schwann cells
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原代培养感觉和运动雪旺细胞生物学特性的比较
DOI：
10.1016/j.neulet.2012.05.059
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发表时间：
2012-07-11
影响因子：
2.5
通讯作者：
Ding, Fei
中科院分区：
文献类型：
--
作者：
He, Qianru;Man, Lili;Ding, Fei
雪旺细胞（SCs）表达不同的感觉和运动表型，这与轴突生长的模式特异性促进有关。本研究比较了原代培养的感觉和运动SCs的细胞增殖和迁移，并测定了两种表型SCs中nap1l1、dok4、lpp、mmp-9和11cam等基因的mRNA表达。结果表明，感觉SCs的细胞增殖或迁移率高于运动SCs， 5种增殖或迁移相关基因在感觉SCs中的表达也高于运动SCs。这些发现为深入研究感觉和运动SCs之间的生物学差异提供了基础。2012爱思唯尔爱尔兰有限公司版权所有。
Schwann cells (SCs) express distinct sensory and motor phenotypes, which are associated with modality-specific promotion of axon growth. Here we compared cell proliferation and migration of primary cultured sensory and motor SCs and determined the mRNA expression of several genes, nap1l1, dok4, lpp, mmp-9 and l1cam, in two phenotypes of SCs. The results showed that the rate of cell proliferation or migration was higher in sensory SCs than in motor SCs, and the five proliferation or migration-related genes also had higher expression in sensory SCs than in motor SCs. These findings may provide a basis for deeply studying the biological differences between sensory and motor SCs. (C) 2012 Elsevier Ireland Ltd. All rights reserved.