A comparison of upper limb function in subjects with multiple sclerosis and healthy controls using an inertial measurement unit
A comparison of upper limb function in subjects with multiple sclerosis and healthy controls using an inertial measurement unit
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DOI：
10.1016/j.msard.2021.103036
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发表时间：
2021-05-27
影响因子：
4
通讯作者：
Tacchino, A.
中科院分区：
文献类型：
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作者：
Di Giovanni, R.;Solaro, C.;Tacchino, A.
上肢功能障碍常见于多发性硬化症（PwMS）患者。提出了几种UL功能的客观度量；然而，它们的使用大多局限于评估轻度至中度残疾和需要精细运动技能的受试者，通常在高残疾水平的受试者中受损。因此，缺乏一种在疾病晚期对UL功能进行评分的工具。本研究的目的是使用15秒手指到鼻子测试（FNT）的仪器版本（惯性测量单元，IMU），分析和比较健康对照组（HC）和PwMS在不同残疾水平下的UL单侧和双侧运动。每个运动周期被划分为前进/调整/返回阶段。手间间隔（IHI）允许评估每个阶段的双边协调（即同步）。IHI越大，双侧协调功能障碍越严重。在对PwMS进行残疾水平分层（PwMSLOW，扩展残疾状态量表，EDSS = 6）后，对IHI的方差分析显示PwMS和HC之间存在显著差异(p
Upper limbs (UL) dysfunction is frequent in people with Multiple Sclerosis (PwMS). Several objective measures of UL function are proposed; however, their use is mostly confined to assess subjects with mild-to-moderate disability and requires fine motor skills, often impaired in high disability level subjects. Thus, a tool to score UL function in the advanced disease stage is lacking. The aim of the study is to analyse and compare UL unilateral and bilateral movements of healthy control (HC) and PwMS, at different disability levels, using an instrumented version (Inertial Measurement Unit, IMU) of the 15-seconds finger-to-nose test (FNT). Each movement cycle was segmented in going/adjusting/returning phases. The inter-hand interval (IHI) allowed assessing bilateral coordination (i.e. synchrony) in each phase. The larger IHI, the more severe the bilateral coordination impairment is. After stratifying PwMS for disability level (PwMSLOW, Expanded Disability Status Scale, EDSS = 6), the ANOVA on IHI showed significant differences between PwMS and HC (p