Effects of methylphenidate on young adults' performance and event-related potentials in a vigilance and a paired-associates learning test.
Effects of methylphenidate on young adults' performance and event-related potentials in a vigilance and a paired-associates learning test.
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哌醋甲酯对年轻人在警惕性和配对联想学习测试中的表现和事件相关电位的影响。
DOI：
10.1111/j.1469-8986.1984.tb00247.x
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发表时间：
1984
期刊：
影响因子：
3.7
通讯作者：
L. Salzman
中科院分区：
文献类型：
--
作者：
J. Strauss;J. Lewis;R. Klorman;L. Péloquin;R. Perlmutter;L. Salzman
22名正常青年男性接受了哌醋甲酯20 mg和安慰剂的平衡和双盲给药。两个任务进行管理的平衡顺序：不间断的45分钟的警惕性测试和成对的同事学习测试。如前所述，在安慰剂组中，准确度和速度在守夜过程中单调下降。这种性能的下降被兴奋剂药物显着减少。事件相关电位（ERP）的正确检测的目标和非目标。最显著的药理学效应涉及被识别为P3b的晚期正波（P464）。哌醋甲酯逆转或减少了安慰剂治疗阶段P464振幅的降低和潜伏期的增加。结果表明，兴奋剂诱导的性能改善可能是介导的评价过程的增强。
在配对试验中，没有药理作用。相反，在第二次会议上，无论给予何种物质，学习都有意想不到的明显改善。然而，每对“刺激”线索诱发的ERP与学习标准的实现有系统的关系。P3b（P555）在获得学习后的振幅显著增加，这是一种晚期阳性。在标准后早期、标准后晚期或过度学习阶段诱发的ERP之间没有幅度变化。早期和晚期前标准类别之间也没有振幅变化。因此，ERP幅度与学习成绩呈二元相关。
Twenty-two normal young men received a counterbalanced and double blind administration of 20 mg methylphenidate and placebo. Two tasks were administered in counterbalanced order: an uninterrupted 45-min vigilance test and a paired-associates learning test. As previously reported, under placebo, accuracy and speed decreased monotonically over the course of the vigil. This degradation of performance was significantly reduced by the stimulant drug. Event-related potentials (ERPs) were derived for correctly detected targets and nontargets. The most salient pharmacologic effects involved a late positive wave (P464) identified as P3b. Methylphenidate reversed or reduced the decrease in amplitude and increase in latency of P464 present over phases of the placebo session. The results suggest that the stimulant-induced improvement in performance may be mediated by enhancement of evaluation processes.
In the paired-associates test there were no pharmacologic effects. Instead there was an unexpected, pronounced improvement in learning in the second session, irrespective of the substance administered. However, the ERP evoked by the “stimulus” cue of each pair was systematically related to the achievement of learning criteria. A late positive was identified as P3b (P555) increased significantly in amplitude following the attainment of learning. There were no amplitude changes among ERPs evoked in the early post-criterion, late post-criterion, or overlearning “phases.” Nor were there amplitude changes between early and late pre-criterion categories. Thus, ERP amplitude displayed a binary association with the achievement of learning.
影响因子：
--
作者：
D. Stuss;A. Toga;J. Hutchison;T. Picton
通讯作者：
D. Stuss;A. Toga;J. Hutchison;T. Picton
多动儿童哌甲酯引起的视觉诱发电位变化：剂量/反应效应。
DOI：
10.1016/0013-4694(83)90203-1
发表时间：
1983
期刊：
Electroencephalography and clinical neurophysiology
影响因子：
--
作者：
Halliday,R;Callaway,E;Naylor,H
通讯作者：
Naylor,H