LGICdb: a manually curated sequence database after the genomes.

LGICdb: a manually curated sequence database after the genomes.
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DOI:
10.1093/nar/gkj104
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发表时间:
2006-01-01
影响因子:
14.9
通讯作者:
Le Novere, Nicolas
Le Novere, Nicolas
中科院分区:
生物学2区
文献类型:
--
作者:
Donizelli, Marco;Djite, Marie-Ange;Le Novere, Nicolas

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配体门控离子通道形成由化学物质结合控制的跨膜离子孔。 LGICdb 的目标是成为一种非冗余的、手动管理的资源,提供对组成细胞外激活的配体门控离子通道的大量亚基的访问,例如烟碱、ATP、GABA 和谷氨酸离子型受体。 XML 本机数据库由 500 多个人工管理的条目组成,已于 2004 年迁移至 EBI。其设施通过新的搜索系统、定制的多序列比对和蛋白质结构的操作得到了增强()。尽管通用序列资源有了巨大的改进,LGICdb 仍然提供其他地方无法提供的序列。
Ligand-gated ion channels form transmembrane ionic pores controlled by the binding of chemicals. The LGICdb aims to be a non-redundant, manually curated resource offering access to the large number of subunits composing extracellularly activated ligand-gated ion channels, such as nicotinic, ATP, GABA and glutamate ionotropic receptors. Composed of more than 500 human curated entries, the XML native database has been relocated in 2004 to the EBI. Its facilities have been enhanced with a new search system, customized multiple sequence alignments and manipulation of protein structures (). Despite the vast improvement of general sequence resources, the LGICdb still provide sequences unavailable elsewhere.
DOI: 10.1126/science.1112014
发表时间: 2005-09-02
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