From Drosophila segmentation to human cancer therapy
From Drosophila segmentation to human cancer therapy
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DOI：
10.1242/dev.168898
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发表时间：
2018-11-01
期刊：
影响因子：
4.6
通讯作者：
Ingham, Philip W.
中科院分区：
文献类型：
--
作者：
Ingham, Philip W.
Hedgehog信号首先在果蝇中被描述，是胚胎发育和组织稳态的关键调节因子，其功能障碍是各种人类先天性异常和疾病的基础。虽然现在被认为是癌症治疗的主要靶点以及定向干细胞分化的介体，但Hedgehog信号传导的功能和机制的揭示主要是由对基础发育生物学的兴趣而不是临床需求驱动的。在这里，我描述了对胚胎模式的好奇心如何导致识别刺猬信号蛋白家族和转导其活性的途径，并最终开发出阻断这一途径的药物。
First described in Drosophila, Hedgehog signalling is a key regulator of embryonic development and tissue homeostasis and its dysfunction underlies a variety of human congenital anomalies and diseases. Although now recognised as a major target for cancer therapy as well as a mediator of directed stem cell differentiation, the unveiling of the function and mechanisms of Hedgehog signalling was driven largely by an interest in basic developmental biology rather than clinical need. Here, I describe how curiosity about embryonic patterning led to the identification of the family of Hedgehog signalling proteins and the pathway that transduces their activity, and ultimately to the development of drugs that block this pathway.