Correlation of observed fold frequency with the occurrence of local structural motifs
Correlation of observed fold frequency with the occurrence of local structural motifs
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DOI：
10.1006/jmbi.1999.2642
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发表时间：
1999-04-16
影响因子：
5.6
通讯作者：
Thornton, JM
中科院分区：
文献类型：
--
作者：
Salem, GM;Hutchinson, EG;Thornton, JM
众所周知，一些蛋白质折叠（超折叠）非常频繁地发生。我们发现，与其他折叠相比，大多数超折叠结构在超二级结构的三个基本单元（α-发夹、β-发夹或β-α-β-单元）之一中具有更高比例的α-螺旋或β-链残基。此外，通过考虑两个更复杂的基序，四链希腊键（β（4））和β alpha-希腊语键（beta alpha beta beta），我们证明了剩余的超折叠结构包含许多这些三维堆积的高阶单元。讨论了这些结果对折叠的影响。 (C) 1999 年学术出版社。
It is well known that some protein folds (superfolds) occur very frequently. We show that compared to other folds, most superfold structures have a higher proportion of their alpha-helical or beta-strand residues in one of three basic units of supersecondary structure (alpha-hairpin, beta-hairpin or beta alpha beta-unit) Furthermore, by taking into consideration two more complex motifs, the four-stranded Greek-key (beta(4)) and the beta alpha-Greek key (beta alpha beta beta), we demonstrate that the remaining superfold structures contain many of these higher order units of three-dimensional packing. The implications of these results for folding are discussed. (C) 1999 Academic Press.