Hair testing and self-report of cocaine use
Hair testing and self-report of cocaine use
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DOI：
10.1016/j.forsciint.2011.05.007
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发表时间：
2012-02-10
影响因子：
2.2
通讯作者：
Groppi, Angelo
中科院分区：
文献类型：
--
作者：
Vignali, Claudia;Stramesi, Cristiana;Groppi, Angelo
毛发分析在临床和法医领域都是一种有用的工具：它可以获得有关滥用药物（DOA）消费的信息。然而，尽管分析结果，有时病人继续否认使用药物，或相反，坚持将自己描述为严重的药物成瘾者;事实上，在获得关于药物使用的真实的数量的真实陈述方面，往往有相当大的困难。我们招募了113名受试者（61名非洲人，52名白人），他们最近被送进监狱。他们被要求讲述他们在过去三个月内使用非法药物的情况，然后接受头发分析。通过GC-MS分析毛发段（3cm）的安非他明、可卡因和阿片类药物。从82名受试者中获得了有用的数据，根据种族来源（非洲人或高加索人）分为两个主要组，并进一步分为每日、每周和每月使用者。结果表明，定性结果和自我报告的消费是在良好的协议，虽然消费频率和浓度之间的相关性在头发中显示有时较高的浓度与低消费的入场相比。偶尔使用和每日使用之间存在明确的分离（特别是在高加索人中），而报告每周使用的浓度变化更大。在非洲人头发中测得的可卡因浓度比高加索人高得多，即使这项研究完全基于自我报告，它也提供了一些有趣的信息，以区分消费频率，特别是强调了头发分析中种族偏见的重要性。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Hair analysis is a useful tool in both clinical and forensic fields: it allows information about drugs of abuse (DOA) consumption to be obtained. However, in spite of analytical results, sometimes patients continue to deny using drugs or, on the contrary, insist on describing themselves as severe drug addicts; indeed there are often considerable difficulties in getting truthful statements about the real amount of drugs used.In this study we have tried to compare cocaine concentration in hair samples with self-reported drug intake. We enrolled 113 subjects (61 Africans, 52 Caucasians) who had been recently sent to jail. They were asked to tell about their use of illicit drugs during the last three months and then submitted to hair analysis. Hair segments (3 cm) were analyzed by GC-MS for amphetamines, cocaine and opiates. Useful data was obtained from 82 subjects, separated into two main groups on account of ethnic origin (African or Caucasian) and divided further into daily, weekly and monthly users. The results showed qualitative results and self-reported consumption to be in good agreement, although the correlation between frequency of consumption and concentration in hair revealed sometimes higher concentrations in contrast with the admission of low consumption. There was a definite separation between occasional and daily use (especially in Caucasian people), while concentrations found where weekly use was reported were more variable. Concentrations of cocaine measured in Africans' hair were much higher than in Caucasians'.Even if this study is exclusively based on self-report, it provides some interesting information in order to differentiate the frequency of consumption, and especially underlines the great importance of ethnic bias on hair analysis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.