Reversible color vision loss in occupational exposure to metallic mercury
Reversible color vision loss in occupational exposure to metallic mercury
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DOI：
10.1006/enrs.1997.3814
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发表时间：
1998-05-01
影响因子：
8.3
通讯作者：
Gobba, F
中科院分区：
文献类型：
--
作者：
Cavalleri, A;Gobba, F
在21名汞暴露工人和性别、年龄、吸烟和饮酒习惯相匹配的参照物中评估了色觉。应用Lanthony 15 Hue去饱和面板（D-15 d）。在工人中，平均尿汞（HgU）为115 +/- 61.5 μ g/g肌酐;除一人外，所有人的值都超过了美国政府工业卫生学家会议提出的生物限值（BEI）。与对照组相比，汞暴露工人出现了剂量相关的亚临床色觉损害。在调查之后，工作条件得到了改善。12个月后，工人们被重新检查。平均HgU为10.0 μ g/g肌酐，没有受试者超过BEI。色觉显着改善相比，第一次检查，此外，没有观察到暴露工人和参照之间的差异。研究结果进一步证明，在研究的第一部分中观察到的色觉丧失与汞暴露有关，而且表明这种影响是可逆的。这些数据表明，金属汞可以引起可逆的损害色觉。这表明，在汞早期效应的研究中应包括色觉测试，并考虑将D-15 d作为汞接触工人生物学监测的早期效应指标。(C)北京：科学出版社.
Color vision was evaluated in twenty-one mercury exposed workers and referents matched for sex, age, tobacco smoking, and alcohol habits. The Lanthony 15 Hue desaturated panel (D-15 d) was applied. In the workers, mean urinary Hg (HgU) was 115 +/- 61.5 mu g/g creatinine; in all but one the values exceeded the biological limit (BEI) proposed by the American Conference of Governmental Industrial Hygienists. A dose-related subclinical color vision impairment was observed in Hg-exposed workers compared to the referents. Just after the survey, working conditions were improved. Twelve months later the workers were reexamined. Mean HgU was 10.0 mu g/g creatinine and in no subjects was the BEI exceeded. Color perception was significantly improved compared to the first examination and, furthermore, no differences were observed between exposed workers and referents. The results add evidence that the color vision loss observed during the first part of the study was related to Hg exposure and, moreover, show that this effect is reversible. These data indicate that metallic Hg can induce a reversible impairment in color perception. This suggests that color vision testing should be included in studies on the early effects of Hg, The possibility of applying the D-15 d as an early effect index in the biological monitoring of Hg exposed workers should also be entertained. (C) 1998 Academic Press.