Small-bowel perfusion measurement: Feasibility with single-compartment kinetic model applied to dynamic contrast-enhanced CT
Small-bowel perfusion measurement: Feasibility with single-compartment kinetic model applied to dynamic contrast-enhanced CT
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DOI：
10.1148/radiol.2372041403
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发表时间：
2005-11-01
期刊：
影响因子：
19.7
通讯作者：
Sheiman, RG
中科院分区：
文献类型：
--
作者：
Sitek, A;Sheiman, RG
本研究经机构审查委员会批准，符合HIPAA。获得所有患者的知情同意书。本研究的目的是前瞻性地检查通过使用运动校正、对比度增强计算机断层扫描（CT）图像和单室动力学模型测量小肠定量血流量的可行性。7例患者接受腹部CT，其中40个10 mm厚的切片在一个单一的水平。造影剂给药后，每隔3秒获取一次小肠图像。感兴趣区域的自动应用产生了肠壁和主动脉的时间增强曲线。将一室模型应用于每组时间增强曲线I，以确定小肠体积血流量F-v、分布容积VD和血液通过时间τ。还通过使用首过法和伽马变量分析计算F-v以进行模型验证。用单室模型获得的Fv值（平均F-v，0.47 min（-1））与用首过法（Pearson r = 0.80）和γ变量分析（Pearson r = 0.97）获得的Fv值显示出良好的线性相关性。平均V-D和tau值分别为2.86（无单位）和4.28秒。一室动力学模型可应用于运动校正的对比度增强的小肠CT图像，以量化灌注。(c)RSNA，2005年。
This study was institutional review board approved and HIPAA compliant. Informed consent was obtained from all patients. The purpose of the,study was to prospectively examine the feasibility of measuring small-bowel quantitative blood flow by using motion-corrected, contrast-enhanced computed, tomographic (CT) images and a single-compartment kinetic model. Seven patients underwent abdominal CT in which 40 10-mm-thick sections were obtained at a single level. Small-bowel images were obtained every 3 seconds after contrast agent administration. Automated application of regions of interest yielded time-enhancement curves for the bowel wall and the aorta. A one-compartment model was applied to each set of time-enhancement curves I for determination of the small-bowel volumetric blood flow F-v, volume of distribution VD, and blood transit time tau. F-v was also calculated by using the first-pass method and gamma variate analysis for model validation. The Fv values obtained by using the single-compartment model (mean F-v, 0.47 min(-1)) showed excellent linear correlation with those obtained by using the first-pass method (Pearson r = 0.80) and gamma variate analysis (Pearson r = 0.97). Mean V-D and tau values were 2.86 (unit-less) and 4.28 seconds, respectively. A one-compartment kinetic model can be applied to motion-corrected, contrast-enhanced small-bowel CT images to quantify perfusion. (c) RSNA, 2005.