Descendant family history of atopic dermatitis.
Descendant family history of atopic dermatitis.
复制标题
后代有特应性皮炎家族史。
作者：
M. Uehara;C. Kimura
对270例成人特应性皮炎患者及其529名儿童进行了遗传家族史检查。在529名儿童中，316名（60%）有异位性皮炎病史。男孩和女孩同样受到影响。在配偶无特应性皮炎和呼吸道特应性病史的患者中，受累儿童的患病率为56%（180/321），在配偶有特应性皮炎病史的患者中为81%（48/59），在配偶仅有呼吸道特应性病史的患者中为59%（88/149）。这些结果表明特应性皮炎的遗传方式为常染色体显性遗传。他们还表明，遗传背景的特应性皮炎是不相同的呼吸道特应性。
Descendant family history of atopic dermatitis was examined in 270 adult patients with this skin disease and their 529 children. Of the 529 children, 316 (60%) had a history of atopic dermatitis. Boys and girls were equally affected. The prevalence of affected children was 56% (180/321) in those patients whose spouses did not have a history of both atopic dermatitis and respiratory atopy, 81% (48/59) in those patients whose spouses had a history of atopic dermatitis, and 59% (88/149) in those patients whose spouses had a history of respiratory atopy only. These results indicate that the mode of inheritance of atopic dermatitis is autosomal dominant. They also suggest that the genetic background of atopic dermatitis is not identical with that of respiratory atopy.