Hemangiopericytoma of the head and neck
Hemangiopericytoma of the head and neck
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DOI：
10.1097/00005537-199909000-00009
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发表时间：
1999-09-01
期刊：
影响因子：
2.6
通讯作者：
Kraus, DH
中科院分区：
文献类型：
--
作者：
Carew, JF;Singh, B;Kraus, DH
目的/假设：血管外皮细胞瘤是一种罕见的肿瘤，起源于血管，可能发生在头部和颈部，其罕见的发生和可变的恶性潜力有限的尝试，以确定其临床行为。本研究回顾了在一个单一的机构治疗头颈部血管外皮细胞瘤的经验。研究设计：回顾性。方法：回顾性分析1979 ~ 1995年收治的12例头颈部血管外皮细胞瘤的临床资料。原发部位：颈部4例，口腔3例，腮腺2例，眼眶1例，上颌窦1例，下颌骨1例。5例患者的病变组织学特征为高或中等级别，6例患者的病变组织学特征为低级别。结果如下：9名患者接受了根治性治疗; 3名患者出现肺转移（2）或不可切除的原发灶（1），并接受了放射治疗和/或基于阿霉素的姑息性化疗。接受根治性治疗的患者接受了根据肿瘤位置和大小决定的各种手术切除。4例患者接受了中位剂量为60戈伊的术后放疗，用于治疗手术切缘阳性（2例）、高级别组织学（1例）或复发性病变（1例）。手术治疗患者的5年总生存率为87.5%，1例复发性高级别病变患者在局部、区域和远处部位失败，发生了一例死亡。中位随访生存期为73个月。结论：血管外皮细胞瘤的临床表现与其组织学分级有关。积极的局部治疗，包括手术和放射治疗似乎是有效的，在提供肿瘤控制。
Objective/Hypothesis: Hemangiopericytomas are uncommon neoplasms of vascular origin that may arise in the head and neck Their rare occurrence and variable malignant potential have limited attempts to characterize their clinical behavior. This study reviews the experience in treating hemangiopericytomas of the head and neck at a single institution. Study Design: Retrospective. Methods: The records of 12 patients with hemangiopericytomas of the head and neck presenting between 1979 and 1995 were reviewed. Site of origin included the neck (4), oral, cavity (3), parotid (2), orbit (1), maxillary sinus (1) and mandible (1). Five patients had lesions characterized as high or intermediate grade histologically, and six had lesions characterized as low grade. Results: Nine patients were treated with curative intent; three presented either with pulmonary metastasis (2) or unresectable primaries (1) and were treated with radiation therapy and/or palliative Adriamycin-based chemotherapy, Patients treated with curative intent underwent a variety of surgical resections dictated by tumor location and size. Four patients received postoperative radiation therapy to a median dose of 60 Gy, for positive surgical margins (2), high-grade histology (1) or a recurrent lesion (1), Five-year overall survival in patients treated surgically was 87,5%, A single mortality occurred in a patient with a recurrent high-grade lesion who failed at local, regional, and distant sites. Median follow-up off survivors was 73 months. Conclusion: The clinical behavior of hemangiopericytomas appears to be related to their histological grade. Aggressive local therapy including surgery and radiation therapy appears to be effective int providing tumor control.