[Invasive aspergillosis in Castilla y Leon and Cantabria: years 1998 and 1999].
[Invasive aspergillosis in Castilla y Leon and Cantabria: years 1998 and 1999].
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发表时间：
2001-06
影响因子：
1.9
通讯作者：
R. López-Medrano;Grupo de Microbiólogos de la Sociedad Castellano-Leonesa Microbiología-Grupo-de-Microbiólogos-de-la-Sociedad-Microbiología-2253689663
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作者：
R. López-Medrano;Grupo de Microbiólogos de la Sociedad Castellano-Leonesa Microbiología-Grupo-de-Microbiólogos-de-la-Sociedad-Microbiología-2253689663
侵袭性曲霉病（IA）是一种危及生命的真菌病，表现出快速的临床病程，影响免疫抑制的人，特别是患有白血病或接受器官移植计划的患者。这项工作的目的是显示流行病学关注IA在卡斯蒂利亚-莱昂和坎塔布里亚：疾病的发病率，主要的临床表现，基础疾病和诊断规则在实验室。患者和方法50例IA从卡斯蒂利亚-莱昂和坎塔布里亚国家在两年（1998-1999年）的回顾性研究。包括14个主要机构在内的流行病学、临床和诊断特征在一个单一的数据库中进行了登记和核算。结果大多数IA病例记录在拥有血液学单位或器官移植项目的主要机构。侵袭性肺曲霉菌病是主要特征（39/50例），表现为严重的基础疾病（25/50例）或器官移植后（15/50例）。仅10例侵袭性肺曲霉病和11例IA肺外分期获得明确诊断。在大量病例（44/50例）中，开发了常规微生物程序（42/50例显示培养阳性）。对8例病例进行了血清学调查。依赖于抗曲霉抗体的血清学问题显示没有诊断价值。烟曲霉菌是IA中最常见的菌种（33/44例）。结论：据报道，在这个国家，这种疾病的发病率很低：在两年的时间里，在14家医院机构中有50例。我们观察到大多数病例在大型医院中心进行移植手术。侵袭性肺曲霉病是免疫抑制患者的主要临床表现。微生物学诊断问题依赖于常规方法，特别是培养。
BACKGROUND Invasive aspergillosis (IA) is a life-threatening mycosis showing a fast clinical course, affecting immunosupressed people particularly patients suffering leukemia or following organ transplantation programs. The aim of this work is to show epidemiologycal concerns about IA in Castilla y Leon and Cantabria: the disease's incidence, the main clinical presentations, the underlaying diseases and diagnostic rules in the laboratory. PATIENTS AND METHODS 50 cases of IA were obtained from the countries of Castilla y Leon and Cantabria in a two-years (1998-1999) retrospective study. Epidemiology, clinical and diagnostic features including the 14 main institutions were registered and accounted in a single data base. RESULTS The majority of IA cases were recorded in major institutions possessing haematology units or organ transplantation programs. Invasive pulmonary aspergillosis was the main feature (39/50 cases) showing serious underlying diseases (25/50 cases) or following organ transplantation programs (15/50 cases). Certain diagnosis was obtained for only ten cases of invasive pulmonary aspergillosis and eleven cases of extrapulmonary stages of IA. In a high number of cases (44/50 cases) conventional microbiological procedures (42/50 showing positive cultures) were developed. Serology investigations were undertaken in eight cases. Serological issues relying on anti-Aspergillus antibodies showed no diagnostic value. Aspergillus fumigatus was the most common species involved in IA (33/44 cases). CONCLUSIONS A low incidence of the disease in this country was reported: with 50 cases in 14 hospital institutions during a two-year period. We observed most cases in large hospital centres performing transplant operations. Invasive pulmonary aspergillosis was the main clinical setting in immunosupressed patients. Microbiology diagnostic issues relied on conventional methods in particularly on culture.