Distribution of the neuronal specific protein, 14-3-2, in central nervous system lesions of tuberous sclerosis
Distribution of the neuronal specific protein, 14-3-2, in central nervous system lesions of tuberous sclerosis
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神经元特异性蛋白 14-3-2 在结节性硬化症中枢神经系统病变中的分布
DOI：
10.1007/bf00689991
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发表时间：
2004
影响因子：
12.7
通讯作者：
Robert L. Wollmann
中科院分区：
文献类型：
--
作者：
Kari Stefansson;Robert L. Wollmann
本文用抗14-3-2血清和Sternberger的PAP法研究了结节性硬化症（TS）中枢神经系统（CNS）病变中神经元特异性烯醇化酶（14-3-2）的分布。在皮层块茎中，所有的巨细胞都有强烈的胞质染色。室管膜下结节中仅偶见细胞染色。室管膜下巨细胞瘤中的所有细胞均被强染色。提示皮质巨细胞和室管膜下巨细胞瘤起源于神经元而非星形细胞。
The distribution of a neuronal specific enolase (14-3-2) in the central nervous system (CNS) lesions of tuberous sclerosis (TS) was examined using antiserum to 14-3-2 and the peroxidase antiperoxidase (PAP) method of Sternberger. In cortical tubers all the giant cells had intense cytoplasmic staining. Only occasional cells in the subependymal nodules were stained. All cells in the subependymal giant cell tumors were intensely stained. This indicates that the cortical giant cells and the giant cell subependymal tumors are of neuronal rather than astrocytic origin.