Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits
Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits
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DOI：
10.1126/science.1121325
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发表时间：
2006-01-13
期刊：
影响因子：
56.9
通讯作者：
Tamás, G
中科院分区：
文献类型：
--
作者：
Szabadics, J;Varga, C;Tamás, G
大脑皮层轴突在轴突初始段接受突触输入几乎完全来自γ -氨基丁酸释放（GABAergic）轴突-轴突细胞（AACs）。在神经元中，轴突的动作电位产生阈值最低；因此，aac被认为是控制神经元输出的战略性抑制神经元。然而，我们发现AACs可以使锥体细胞去极化，并可以在大鼠和人类皮层网络中启动一系列刻板的突触事件，因为轴突相对于周围的gaba能输入具有去极化逆转电位。轴突中没有氯化钾共转运体2支持AACs启动的兴奋和信号传播。
Axons in the cerebral cortex receive synaptic input at the axon initial segment almost exclusively from gamma-aminobutyric acid-releasing (GABAergic) axo-axonic cells (AACs). The axon has the lowest threshold for action potential generation in neurons; thus, AACs are considered to be strategically placed inhibitory neurons controlling neuronal output. However, we found that AACs can depolarize pyramidal cells and can initiate stereotyped series of synaptic events in rat and human cortical networks because of a depolarized reversal potential for axonal relative to perisomatic GABAergic inputs. Excitation and signal propagation initiated by AACs is supported by the absence of the potassium chloride cotransporter 2 in the axon.