INTERLEUKIN-1 STIMULATES FIBROBLASTS TO SYNTHESIZE GRANULOCYTE-MACROPHAGE AND GRANULOCYTE COLONY-STIMULATING FACTORS - MECHANISM FOR THE HEMATOPOIETIC RESPONSES TO INFLAMMATION
INTERLEUKIN-1 STIMULATES FIBROBLASTS TO SYNTHESIZE GRANULOCYTE-MACROPHAGE AND GRANULOCYTE COLONY-STIMULATING FACTORS - MECHANISM FOR THE HEMATOPOIETIC RESPONSES TO INFLAMMATION
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DOI：
10.1172/jci113316
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发表时间：
1988-01-01
影响因子：
15.9
通讯作者：
ADAMSON, JW
中科院分区：
文献类型：
--
作者：
KAUSHANSKY, K;LIN, N;ADAMSON, JW
IL-1是一类在炎症反应中发挥重要作用的多肽家族。这种反应的特征包括促进骨髓中性粒细胞的释放，激活循环和组织相吞噬细胞，以及增加中性粒细胞和单核细胞的产生。我们试图在细胞和分子水平上了解急性和慢性炎症状态下的造血反应。集落刺激因子(CSF)是一种糖蛋白，在体外和体内参与中性粒细胞和单核细胞的产生和激活。我们发现静止期的真皮成纤维细胞在培养过程中组成释放粒细胞-巨噬细胞集落刺激因子(GM-CSF)、粒细胞集落刺激因子(G-CSF)和巨噬细胞集落刺激因子(G-CSF)，并且皮摩尔浓度的炎症介质IL-1至少刺激5倍的GM-CSF和G-CSF的转录和释放。这些发现证实了IL-1通过刺激GM-CSF和G-CSF的产生和释放在造血炎症反应中的作用。
IL-1 is a family of polypeptides which play a critical role in the inflammatory response. Characteristics of this response include an enhanced release of bone marrow neutrophils, activation of circulating and tissue-phase phagocytes, and enhanced production of neutrophils and monocytes. We have sought to understand the hematopoietic response to acute and chronic inflammatory states on a cellular and molecular level. Colony-stimulating factors (CSFs) are glycoproteins involved in the production and activation of neutrophils and monocytes in vitro and in vivo. We have found that quiescent dermal fibroblasts constitutively release granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), and macrophage CSF in culture, and that picomolar concentrations of the inflammatory mediator IL-1 stimulate by at least fivefold the transcription and release of GM-CSF and G-CSF. These findings establish the role of IL-1 in the hematopoietic response to inflammation through the stimulation of the production and release of GM-CSF and G-CSF.