Age-related suppression effect of current body weight on the association between birthweight and blood pressure: The Bogalusa heart study
Age-related suppression effect of current body weight on the association between birthweight and blood pressure: The Bogalusa heart study
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当前体重对出生体重和血压之间关系的年龄相关抑制作用：Bogalusa 心脏研究
DOI：
10.1111/ijpo.12716
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发表时间：
2020
影响因子：
3.8
通讯作者：
Chen Wei
中科院分区：
文献类型：
--
作者：
Yun Miaoying;Wang Xuan;Fan Lijun;Yan Yinkun;Bazzano Lydia;He Jiang;Li Shengxu;Zhang Tao;Chen Wei
背景：在研究出生体重和血压（BP）之间的关系时，是否调整当前体重一直存在争议。目的通过体重指数（BMI）将出生体重对血压的影响分为直接影响和间接影响两部分。方法该研究队列包括6251名参与者，他们有出生体重信息，并在青春期前（4 ~ 11岁）、青春期（12 ~ 19岁）、青年期（20 ~ 30岁）和成年中期（31 ~ 58岁）观察了13 443次BMI和BP。一般的第三变量模型用于区分当前BMI对不同年龄出生体重-血压关联的中介和抑制作用。结果出生体重对收缩压的总影响（不包括当前BMI）在青少年前为0.003 (P= .810)，青少年为- 0.032 (P= .029)，青年为- 0.066 (P= .002)，中年成人为- 0.051 （P= .023）。在对BMI进行额外调整后，出生体重对收缩压的直接影响增强至β= - 0.066 （P= 0.013）、β= - 0.058 （P= 0.014）、β= - 0.094 （P= 0.020）、β= - 0.066 (P= 0.023)；BMI的抑制效应分别为0.070、0.027、0.028和0.015。随着年龄的增长，抑制效应的下降趋势与出生体重- BMI和BMI - BP相关性的趋势相似。结论当前体重对出生体重与血压的相关性具有抑制作用，而非中介作用，其中青春期前的抑制作用最大。抑制作用主要由出生体重- BMI和BMI - BP相关性决定。
BackgroundIt has been controversial whether to adjust for current body weight while examining the relationship between birthweight and blood pressure (BP).ObjectiveThe present study aims to partition the total effect of birthweight on BP into its direct effect and indirect effect through current body mass index (BMI).MethodsThe study cohort consisted of 6251 participants who had birthweight information with 13 443 observations on BMI and BP in pre‐adolescence (4‐11 years), adolescence (12‐19 years), young adulthood (20‐30 years) and mid‐adulthood (31‐58 years). General third‐variable models were used to distinguish the mediation and suppression effects of current BMI on the birthweight‐BP association at different ages.ResultsThe total effect of birthweight on systolic BP measured as standardized regression coefficient (β) without current BMI included in the model was 0.003 (P= .810) in pre‐adolescents, −0.032 (P= .029) in adolescents, −0.066 (P= .002) in young adults and −0.051 (P= .023) in midlife adults. With additional adjustment for BMI, the direct effect of birthweight on systolic BP was strengthened toβ= −0.066 (P= .013),β= −0.058 (P= .014),β= −0.094 (P= .020),β= −0.066 (P= .023); the suppression effects of BMI were calculated at 0.070, 0.027, 0.028 and 0.015 in the respective age groups. The decreasing trend of suppression effects with increasing age mimicked the trends of birthweight‐BMI and BMI‐BP correlations.ConclusionsCurrent body weight has a suppression effect, not a mediation effect, on the birthweight‐BP association, with pre‐adolescents having the greatest suppression effect. The suppression effect is predominantly determined by birthweight‐BMI and BMI‐BP correlations.