Measurement of motor disability in MPTP-treated macaques using a telemetry system for estimating circadian motor activity
Measurement of motor disability in MPTP-treated macaques using a telemetry system for estimating circadian motor activity
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DOI：
10.1016/j.jneumeth.2003.10.017
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发表时间：
2004-03-15
影响因子：
3
通讯作者：
Herrero, MT
中科院分区：
文献类型：
--
作者：
Barcia, C;De Pablos, V;Herrero, MT
灵长类动物MPTP暴露后的帕金森症状可以通过几种视觉方法（经典运动评分）来测量。然而，这些方法有主观偏见，特别是在运动活动的评估方面。计算机监测系统代表了一种无偏倚的方法来测量猴子在MPTP给药后的运动障碍。本研究通过遥测系统测量了MPTP给药前后猴子的运动活动，并与对照组的运动活动进行了比较。服用MPTP后，观察到运动活动明显减少。这些结果表明，所使用的监测方法适合于表征运动能力丧失和治疗后可能的改善，以测试不同的治疗方法来控制涉及灵长类动物的MPTP模型中的帕金森病。(C) 2003 Elsevier B.V.版权所有
The parkinsonian symptoms of primates after MPTP exposure can be measured by several visual methods (classical motor scores). However, these methods have a subjective bias, especially as regards the evaluation of the motor activity. Computerized monitoring systems represent an unbiased method for measuring the motor disability of monkeys after MPTP administration. In this work the motor activity of monkeys before and after MPTP administration is measured and compared with the activity of a control intact group by means of a telemetry system. A pronounced decrease in motor activity was observed after MPTP administration. These results suggest the monitoring method used is suited for characterizing the motor incapacity and possible improvements following treatments to test different therapies to control Parkinson's disease in MPTP models involving primates. (C) 2003 Elsevier B.V. All rights reserved.