Atypical effective connectivity of thalamo-cortical circuits in autism spectrum disorder
Atypical effective connectivity of thalamo-cortical circuits in autism spectrum disorder
复制标题
自闭症谱系障碍中丘脑皮质回路的非典型有效连接
DOI：
10.1002/aur.1614
复制
发表时间：
2016-11-01
期刊：
影响因子：
4.7
通讯作者：
Chen, Huafu
中科院分区：
文献类型：
--
作者：
Chen, Heng;Uddin, Lucina Q.;Chen, Huafu
自闭症谱系障碍 (ASD) 是一种神经发育障碍，其特征是多个大脑系统内部和之间的非典型连接。我们的目的是探索自闭症谱系障碍患者通过丘脑皮质回路从感觉外围到大脑信息处理中心的信息传输。使用了来自自闭症大脑成像数据交换的大型多中心数据集。使用赢者通吃的策略，将来自自动解剖标记图谱的丘脑模板细分为对应于六个皮质区域的六个子区域。然后应用格兰杰因果分析（GCA）来计算从丘脑子区域到相应皮质区域的有效连接。结果表明，与健康对照 (HC) 参与者相比，自闭症谱系障碍 (ASD) 参与者从丘脑到左前额叶皮层 (P=0.023)、右后顶叶皮层 (P=0.03) 和双侧颞叶皮层 (左：P=0.014；右：P=0.015) 的有效连接减少。根据 ASD 组自闭症诊断观察表评估，丘脑-双侧颞叶皮层连接的 GCA 值与沟通评分显着负相关（左：P=0.037；右：P=0.007）。年龄相关分析显示，HC 组丘脑-双侧颞叶皮层连接强度与年龄显着正相关（左：P=0.013；右：P=0.016），而 ASD 组则不然（左：P=0.506；右：P=0.219）。这些结果表明，自闭症谱系障碍患者的丘脑-皮质信息传输受损，并表明丘脑-颞叶皮层连接的非典型发育可能与该疾病的沟通缺陷有关。自闭症研究2016，9：1183-1190。 (c) 2016 年国际自闭症研究学会，Wiley periodicals, Inc.
Autism spectrum disorder (ASD) is a neurodevelopment disorder characterized by atypical connectivity within and across multiple brain systems. We aimed to explore information transmission from the sensory periphery to information processing centers of the brain across thalamo-cortical circuits in ASD. A large multicenter dataset from the autism brain imaging data exchange was utilized. A thalamus template derived from the Automatic Anatomic Labeling atlas was subdivided into six subregions corresponding to six cortical regions using a winner-takes-all strategy. Granger causality analysis (GCA) was then applied to calculate effective connectivity from subregions of the thalamus to the corresponding cortical regions. Results demonstrate reduced effective connectivity from the thalamus to left prefrontal cortex (P=0.023), right posterior parietal cortex (P=0.03), and bilateral temporal cortex (left: P=0.014; right: P=0.015) in ASD compared with healthy control (HC) participants. The GCA values of the thalamus-bilateral temporal cortex connections were significantly negatively correlated with communication scores as assessed by the autism diagnostic observation schedule in the ASD group (left: P=0.037; right: P=0.007). Age-related analyses showed that the strengths of the thalamus-bilateral temporal cortex connections were significantly positively correlated with age in the HC group (left: P=0.013; right: P=0.016), but not in the ASD group (left: P=0.506; right: P=0.219). These results demonstrate impaired thalamo-cortical information transmission in ASD and suggest that atypical development of thalamus-temporal cortex connections may relate to communication deficits in the disorder. Autism Res2016, 9: 1183-1190. (c) 2016 International Society for Autism Research, Wiley Periodicals, Inc.