Biomimetic membrane-conjugated graphene nanoarchitecture for light-manipulating combined cancer treatment in vitro.
Biomimetic membrane-conjugated graphene nanoarchitecture for light-manipulating combined cancer treatment in vitro.
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DOI：
10.1016/j.jcis.2016.07.031
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发表时间：
2016-11
影响因子：
9.9
通讯作者：
Chenchen Qin;J. Fei;P. Cai;Jie Zhao;Junbai Li
中科院分区：
文献类型：
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作者：
Chenchen Qin;J. Fei;P. Cai;Jie Zhao;Junbai Li
我们报道了通过简单的脂质自组装，仿生膜共轭介孔二氧化硅包覆的氧化石墨烯被构建为靶向纳米载体，以实现光热治疗和化疗的有效组合。令人印象深刻的是，用含有叶酸的脂质双层进行简单的表面修饰允许上述石墨烯基纳米结构被过表达相关受体的肿瘤细胞选择性地内化。与纯药物相比，通过纳米结构将7倍多柔比星递送到肿瘤细胞中。细胞内化后，在近红外光照射下，纳米结构中的氧化石墨烯可以将光能转化为热量，部分杀死癌细胞。同时，高温将促使阿霉素从上述纳米结构中快速释放，进一步导致更多癌细胞死亡。因此，与个体化治疗相比，具有更高疗效的综合癌症治疗在体外是可行的。
We report that through facile lipid self-assembly, biomimetic membrane-conjugated mesoporous silica-coated graphene oxide is constructed as targeting nanocarrier toward efficient combination of photothermal therapy and chemotherapy. Impressively, the simple surface modification with folate-contained lipid bilayer allows the graphene-based nanoarchitecture above to be selectively internalized by tumor cells overexpressing relevant receptors. Compared to pure drug, 7-fold doxorubicin is delivered into tumor cells by the nanoarchitecture. After cellular internalization, upon near infrared light illumination, graphene oxide in the nanoarchitecture can convert light energy into heat to kill cancer cells partially. Simultaneously, hyperthermia will drive rapid release of doxorubicin from the nanoarchitecture above to further cause the death of more cancer cells. Thus, integrated cancer treatment with higher efficacy is achievedin vitrocompared to that of individual therapy.