Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours.
Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours.
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DOI：
10.1038/bjc.1987.213
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发表时间：
1987-10
影响因子：
8.8
通讯作者：
Kelly DA
中科院分区：
文献类型：
--
作者：
Raleigh JA;Miller GG;Franko AJ;Koch CJ;Fuciarelli AF;Kelly DA
多克隆抗体已提出了在兔子的血蓝蛋白加合物的还原活化，氟化类似物的米索硝唑。荧光免疫组织化学研究表明，多克隆抗体结合到球状体部分和肿瘤部分的模式相似的放射自显影研究与氚标记的衍生物的氟化米索硝唑类似物。
Polyclonal antibodies have been raised in rabbits to a haemocyanin adduct of a reductively-activated, fluorinated analogue of misonidazole. Fluorescence immunohistochemical studies show that the polyclonal antibodies bind to spheroid sections and tumour sections in patterns similar to those revealed by autoradiographic studies with a tritium-labelled derivative of the fluorinated misonidazole analogue.