Bottlenecks in HIV-1 transmission: insights from the study of founder viruses.
Bottlenecks in HIV-1 transmission: insights from the study of founder viruses.
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DOI：
10.1038/nrmicro3471
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Cohen MS
中科院分区：
文献类型：
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作者：
Joseph SB;Swanstrom R;Kashuba AD;Cohen MS
HIV-1感染通常是由单一病毒变体（传播/创始者（T/F）病毒）的传播引起的。对这些HIV-1变异体的研究提供了关于传播瓶颈和在传播液和受体组织中作用于病毒的选择性压力的关键信息。这些研究表明，T/F病毒的表型是由随机和选择性的力量，限制传播，并可能是预防策略的目标。在这篇综述中，我们强调了T/F病毒的研究如何有助于更好地了解HIV-1传播的生物学，并讨论了这些研究结果如何影响HIV-1预防策略。
HIV-1 infection typically results from the transmission of a single viral variant, the transmitted/founder (T/F) virus. Studies of these HIV-1 variants provide critical information about the transmission bottlenecks and the selective pressures acting on the virus in the transmission fluid and in the recipient tissues. These studies reveal that T/F virus phenotypes are shaped by stochastic and selective forces that restrict transmission and may be targets for prevention strategies. In this Review, we highlight how studies of T/F viruses contribute to a better understanding of the biology of HIV-1 transmission and discuss how these findings affect HIV-1 prevention strategies.