Drone transportation of blood products
Drone transportation of blood products
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DOI：
10.1111/trf.13900
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发表时间：
2017-03-01
期刊：
影响因子：
2.9
通讯作者：
Street, Jeff
中科院分区：
文献类型：
--
作者：
Amukele, Timothy;Ness, Paul M.;Street, Jeff
背景小型民用无人机(无人机)是一种运输小型货物的新方式。据我们所知，目前还没有研究考察无人机运输对血液产品的影响，也没有研究描述在无人机运输过程中保持温度控制或成分物理特性的方法。STUDY设计和方法使用无菌技术分离了白细胞减少的红细胞(RBC)和6个分离血小板(PLT)单位。较大的母红细胞和血小板单位，以及六个在收集后24小时内冻结的未解冻血浆单位(FP24)，被放置在冷却器中，连接到无人机上，并在温度记录的情况下飞行长达26.5分钟。实验窗口期间的环境温度在两天内从-1摄氏度到18摄氏度不等。对于PLT和FP24单元，环境温度和单元温度之间的差异约为20摄氏度。飞行后，对RBC亲本单位进行离心和目测溶血；检查PLT的平均PLT体积(MPVS)、pH和PLT计数的变化；检查FP24单元背面冻结的气泡是否有任何大小或形状的变化，作为解冻的证据。结果没有证据表明RBC溶血；PLT计数、PH值或MPVS没有显著变化；FP24气泡没有变化。在运输和飞行过程中，所有单位的温度都保持不变。结论无人机运输对RBC、PLT和FP24单位没有不利影响。这些发现表明，无人机运输系统是运输血液产品的可行选择。
BACKGROUNDSmall civilian unmanned aerial vehicles (drones) are a novel way to transport small goods. To the best of our knowledge there are no studies examining the impact of drone transport on blood products, describing approaches to maintaining temperature control, or component physical characteristics during drone transport.STUDY DESIGN AND METHODSSix leukoreduced red blood cell (RBC) and six apheresis platelet (PLT) units were split using sterile techniques. The larger parent RBC and PLT units, as well as six unthawed plasma units frozen within 24 hours of collection (FP24), were placed in a cooler, attached to the drone, and flown for up to 26.5 minutes with temperature logging. Ambient temperatures during the experimental window ranged between -1 and 18 degrees C across 2 days. The difference between the ambient and unit temperatures was approximately 20 degrees C for PLT and FP24 units. After flight, the RBC parent units were centrifuged and visually checked for hemolysis; the PLTs were checked for changes in mean PLT volumes (MPVs), pH, and PLT count; and the frozen air bubbles on the back of the FP24 units were examined for any changes in size or shape, as evidence of thawing.RESULTSThere was no evidence of RBC hemolysis; no significant changes in PLT count, pH, or MPVs; and no changes in the FP24 bubbles. The temperature of all units was maintained during transport and flight.CONCLUSIONThere was no adverse impact of drone transport on RBC, PLT, or FP24 units. These findings suggest that drone transportation systems are a viable option for the transportation of blood products.