Association of fat distribution differences in infertile women with assisted reproductive outcomes: A prospective cohort study
Association of fat distribution differences in infertile women with assisted reproductive outcomes: A prospective cohort study
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DOI：
10.1002/ijgo.15371
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发表时间：
2024-01-24
影响因子：
3.8
通讯作者：
Wang，Dan-ni
中科院分区：
文献类型：
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作者：
Song，Xiao-huan;Zhu，Meng-li;Wang，Dan-ni
目的探讨脂肪分布对不孕妇女辅助生殖结局的影响。方法随机招募2022年7月至10月在安徽医科大学第一附属医院生殖医学中心接受辅助生殖技术治疗的576名不孕妇女。通过问卷调查和身体成分测量来评估基线信息和脂肪分布。在周期结束时，跟踪卵母细胞，具有两个原核（2PN）的受精卵和可用胚胎的数量。在控制混杂因素的情况下，采用多因素logistic回归模型和限制性三次样条（RCS）曲线模型探讨脂肪分布与生殖结局的关系。结果研究发现，参与者的平均年龄为30.82岁。分析表明，腿体脂肪量（LBFM）与生殖结果分布之间存在显著差异。然而，内脏脂肪水平与生殖结果之间没有显著相关性。考虑混杂因素后，多因素回归分析显示，总体脂质量与卵母细胞数（比值比（OR） 0.92, 95%可信区间（CI） 0.84 ~ 0.99）、2PN （OR 0.92, 95% CI 0.84 ~ 0.99）、可移植胚胎（OR 0.90, 95% CI 0.82 ~ 0.99）呈负相关。RCS模型显示LBFM与辅助生殖结果之间存在线性剂量-反应关系。结论不孕妇女的脂肪分布存在差异，脂肪量越大，辅助生殖效果越差。
ObjectiveTo investigate the impacts of fat distribution on assisted reproductive outcomes in infertile women.MethodsThe study randomly recruited 576 infertile women who underwent assisted reproductive technology treatment at the Reproductive Medicine Center of the First Affiliated Hospital of Anhui Medical University between July and October 2022. Questionnaires and body composition measurements were administered to assess baseline information and fat distribution. The numbers of oocytes, zygotes presenting with two pronuclei (2PN), and available embryos were tracked at the end of the cycle. Multifactorial logistic regression models and restricted cubic spline (RCS) curve models were used to explore the relationships between fat distribution and reproductive outcomes while controlling for confounding factors.ResultsThe study found that the participants had a mean age of 30.82 years. The analysis showed that there was a significant difference between the amount of leg body fat mass (LBFM) and the distribution of reproductive outcomes. However, there was no significant correlation between the level of visceral fat and reproductive outcomes. After taking confounding factors into account, the multifactorial regression analysis showed that the total body fat mass and the number of oocytes (odds ratio (OR) 0.92, 95% confidence interval (CI) 0.84–0.99), 2PN (OR 0.92, 95% CI 0.84–0.99), and embryos available for transfer (OR 0.90, 95% CI 0.82–0.99) were negatively correlated. RCS modeling revealed a linear dose–response relationship between LBFM and assisted reproductive outcomes.ConclusionFat distribution varies among infertile women, and higher amounts of fat are associated with poorer assisted reproductive outcomes.