Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?
Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?
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DOI：
10.1093/schbul/sbi061
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发表时间：
2005-10-01
影响因子：
6.6
通讯作者：
Owen, MJ
中科院分区：
文献类型：
--
作者：
Williams, NM;O'Donovan, MC;Owen, MJ
近年来，基因DTNBP 1（染色体6p 24 -22）已成为精神分裂症最有希望的候选基因之一。在这篇文章中，我们回顾了目前的遗传证据，暗示DTNBP 1作为精神分裂症易感基因。虽然现在有令人印象深刻的支持，从遗传关联研究，重要的是要保持意识到，实际的DTNBP 1易感性变异尚未确定。虽然功能分析使我们能够推测它们可能的功能，但只有当它们被鉴定出来时，我们才能够自信地指定与精神分裂症发病机制相关的基因功能改变的类型。我们希望这将为神经生物学研究开辟新的前景，使我们能够研究DTNBP 1在精神分裂症中的确切作用，其与表型各个方面的关系，以及与其他基因的上位相互作用的潜力，以及基因产物之间的功能相互作用。
Over recent years the gene DTNBP1 (chromosome 6p24-22) has emerged as one of the most promising candidate genes for schizophrenia. In this article, we review the current genetic evidence that implicates DTNBP1 as a schizophrenia-susceptibility gene. While there is now impressive support from genetic association studies, it is important to remain aware that the actual DTNBP1 susceptibility variants have not been identified. While functional analyses have allowed us to speculate their likely function, only when they are identified will we be able to confidently specify the type of altered gene function that is relevant to schizophrenia pathogenesis. This we hope will then open up new vistas for neurobiological research, allowing us to study the exact contribution of DTNBP1 in schizophrenia, its relationships with various aspects of the phenotype, and the potential of epistatic interactions with other genes, as well as functional interactions between the gene products.