Serum levels of endostatin and matrix metalloproteinase-9 associated with high stage and grade primary transitional cell carcinoma of the bladder
Serum levels of endostatin and matrix metalloproteinase-9 associated with high stage and grade primary transitional cell carcinoma of the bladder
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DOI：
10.1016/s0090-4295(02)02429-9
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发表时间：
2003-04-01
期刊：
影响因子：
2.1
通讯作者：
Hou, SK
中科院分区：
文献类型：
--
作者：
Guan, KP;Ye, HY;Hou, SK
目标.分析原发性膀胱移行细胞癌患者术前血清内皮抑素（endostatin）和基质金属蛋白酶-9（MMP-9）水平，并根据肿瘤分期和分级，评价其临床诊断价值。采用酶联免疫吸附法（ELISA）检测52例膀胱移行细胞癌患者（表浅癌13例，晚期癌39例）和32例健康对照者术前血清内皮抑素（endostatin）和MMP-9水平。52例膀胱癌患者血清内皮抑素和MMP-9水平显著高于健康对照组（内皮抑素46.8 ng/mL对30.6 ng/mL，P
Objectives. To analyze the preoperative serum levels of endostatin and matrix metalloproteinase-9 (MMP-9) in patients with primary transitional cell carcinoma of the bladder according to tumor stage and grade and to evaluate their clinical diagnostic application.Methods. Preoperative serum levels of endostatin and MMP-9 were determined in 52 patients with transitional cell carcinoma of the bladder (13 with superficial carcinoma and 39 with advanced carcinoma) and 32 healthy controls by enzyme-linked immunosorbent assay.Results. The serum levels of endostatin and MMP-9 were significantly greater in the 52 patients with bladder cancer than in the healthy controls (endostatin 46.8 ng/mL versus 30.6 ng/mL, P