Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.
Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.
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DOI：
10.1016/s0021-9258(19)37577-5
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发表时间：
1988-10
期刊：
影响因子：
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通讯作者：
T. Kayano;H. Fukumoto;R. Eddy;Y. Fan;M. Byers;T. Shows;G. Bell
中科院分区：
文献类型：
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作者：
T. Kayano;H. Fukumoto;R. Eddy;Y. Fan;M. Byers;T. Shows;G. Bell
编码葡萄糖转运蛋白样蛋白的互补DNA克隆已从人胎儿骨骼肌cDNA文库中分离。496个氨基酸的胎儿肌肉葡萄糖转运蛋白样蛋白与先前描述的人红细胞/HepG 2和肝脏葡萄糖转运蛋白序列分别具有64.4%和51.6%的同一性。RNA印迹研究表明，编码这种葡萄糖转运蛋白样蛋白的转录本存在于大多数组织中，尽管它们的相对丰度不同。编码该蛋白的基因已定位于人类染色体12p13.3。第三种人葡萄糖转运蛋白相关蛋白的鉴定和表征表明，存在一个具有相似序列和结构的蛋白质家族，其参与哺乳动物细胞的营养转运。
Complementary DNA clones encoding a glucose transporter-like protein have been isolated from a human fetal skeletal muscle cDNA library. The 496-amino acid fetal muscle glucose transporter-like protein has 64.4 and 51.6% identity with the previously described human erythrocyte/HepG2 and liver glucose transporter sequences, respectively. RNA blotting studies indicate that transcripts encoding this glucose transporter-like protein are present in most tissues, although their relative abundance varies. The gene encoding this protein has been localized to human chromosome 12p13.3. The identification and characterization of a third human glucose transporter-related protein suggests that there is a family of proteins having similar sequences and structures which are involved in nutrient transport by mammalian cells.