Mediastinal lymphangiomatosis coexisting with occult thymic carcinoma
Mediastinal lymphangiomatosis coexisting with occult thymic carcinoma
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DOI：
10.1007/s00428-006-0333-z
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发表时间：
2007-02
期刊：
影响因子：
3.5
通讯作者：
J. Ikeda;E. Morii;Y. Tomita;Binglin Zhang;T. Tokunaga;M. Inoue;M. Minami;M. Okumura;K. Aozasa
中科院分区：
文献类型：
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作者：
J. Ikeda;E. Morii;Y. Tomita;Binglin Zhang;T. Tokunaga;M. Inoue;M. Minami;M. Okumura;K. Aozasa
纵隔淋巴管瘤病在一个70岁的妇女被诊断的医疗检查。该肿瘤对OK 432或博来霉素的硬化疗法具有抗性。患者继续走下坡路，并在初步诊断后约3年死亡。尸检发现一个巨大的肿瘤肿块占据前纵隔，并牢固地粘附在心包和胸膜上。肿瘤由两个混合的病变：扩张的血管内衬D2-40阳性淋巴管内皮和CD 5阳性非典型细胞巢与局灶性角化。前者被诊断为淋巴管瘤病，后者被诊断为胸腺鳞状细胞癌。血管内皮生长因子（VEGF）-C，一种淋巴管内皮细胞的生长因子，在癌中表达，而VEGF-C受体在淋巴管瘤病的内皮细胞中表达。这些结果表明，VEGF-C来源于胸腺癌诱导淋巴管瘤病病变的旁分泌方式。
Mediastinal lymphangiomatosis in a 70-year-old woman was diagnosed on a medical checkup. The tumor was resistant to sclerotherapy with OK432 or bleomycin. The patient continued on a downhill course and died approximately 3 years after the initial diagnosis. Autopsy revealed a large tumor mass occupying the anterior mediastinum and firmly adhered to the pericardium and the pleura. The tumor consisted of two intermingled lesions: dilated vessels lined with D2-40-positive lymphatic endothelium and CD5-positive atypical cell nests with focal keratinization. The former was diagnosed as lymphangiomatosis and the latter as thymic squamous cell carcinoma. Vascular endothelial growth factor (VEGF)-C, a growth factor for lymphatic endothelial cells, was expressed by the carcinoma, and VEGF-C receptor was expressed by the endothelium of lymphangiomatosis. These findings suggested that VEGF-C derived from the thymic carcinoma induced the lymphangiomatosis lesion in a paracrine manner.