Potential pathophysiological mechanisms in osteonecrosis of the jaw
Potential pathophysiological mechanisms in osteonecrosis of the jaw
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DOI：
10.1111/j.1749-6632.2010.05835.x
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Raghavan, Srikala
中科院分区：
文献类型：
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作者：
Landesberg, Regina;Woo, Victoria;Raghavan, Srikala
双膦酸盐用于治疗恶性肿瘤的高钙血症、与转移性骨病相关的骨骼并发症、佩吉特氏病和骨质疏松症。颌骨坏死(ONJ)是最近描述的一种临床情况，与使用含氮双膦酸盐有关。关于这一实体的报告最早出现在2003年的文献中。虽然已经有相当数量的病例报告以及有限数量的回顾和前瞻性研究来检验与ONJ相关的风险因素，但这种疾病的病理生理学仍然难以捉摸。在这篇综述中，我们探索了ONJ发生的潜在机制，并确定了未来研究的潜在领域。
Bisphosphonates are used in the treatment of hypercalcemia of malignancy, skeletal complications associated with metastastic bone disease, Paget's disease, and osteoporosis. Osteonecrosis of the jaw (ONJ) is a recently described clinical condition that has been associated with the use of nitrogen-containing bisphosphonates. Reports describing this entity first appeared in the literature in 2003. While there have been significant numbers of case reports and a limited number of retrospective and prospective studies examining risk factors associated with ONJ, the pathophysiology of this condition remains elusive. In this review, we explore proposed mechanisms underlying ONJ development and identify potential areas for future investigation.