Scutiaquinones A and B, perylenequinones from the roots of Scutia myrtina with anthelmintic activity
Scutiaquinones A and B, perylenequinones from the roots of Scutia myrtina with anthelmintic activity
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DOI：
10.1021/np0604937
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发表时间：
2007-03-01
影响因子：
5.1
通讯作者：
Singh, Sheo B.
中科院分区：
文献类型：
--
作者：
Ayers, Sloan;Zink, Deborah L.;Singh, Sheo B.
缠绕血圆线虫是一种在牲畜中引起严重感染的蠕虫。用体外杀灭寄生虫的方法，通过生物测定引导的分离方法，从野牡丹根的甲醇提取物中分离得到两个新的萜酮类化合物，分别为灯盏乙素A(1)和灯盏花素B(2)。化合物1和2的结构经1D、2D-核磁共振和MS分析得到确证。报道了化合物1和2的分离、结构和驱虫活性。
Haemonchus contortus is a worm that causes serious infections in livestock. Two new perylenequinones, scutiaquinone A (1) and scutiaquinone B (2), have been isolated from a methanol extract of the roots of Scutia myrtina by bioassay-guided fractionation, using an assay that kills this parasite in vitro. The structures of compounds 1 and 2 were elucidated by analysis of their 1D- and 2D-NMR and MS spectra. The isolation, structure, and anthelmintic activities of compounds 1 and 2 are reported.