Correlation between Retinal Changes and Visual Function in Late-Stage Vogt-Koyanagi-Harada Disease: An Optical Coherence Tomography Study.
Correlation between Retinal Changes and Visual Function in Late-Stage Vogt-Koyanagi-Harada Disease: An Optical Coherence Tomography Study.
复制标题
晚期 Vogt-小柳-原田病视网膜变化与视觉功能的相关性：光学相干断层扫描研究
DOI：
10.1155/2015/916485
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发表时间：
2015
影响因子：
1.9
通讯作者：
Chang Q
中科院分区：
文献类型：
--
作者：
Zhou M;Jiang C;Gu R;Sun Z;Huynh N;Chang Q
目的.描述晚期Vogt-Koyanagi-Harada（VKH）病的光学相干断层扫描（OCT）表现及其与视功能的相关性。方法.回顾性审查了晚期VKH疾病（定义为自疾病发作≥12个月）患者的记录。分析重点是OCT结果和微视野检查，以及形态学和功能结果之间的可能相关性。结果共纳入29例患者（58只眼）。平均发病年龄为34.24 ± 10.67岁。OCT显示主要累及视网膜外层和视网膜色素上皮（RPE）。这些影响包括RPE增厚和锥体外段尖端（COST）线和/或内段/外段（IS/OS）连接的断裂或消失。COST线和IS/OS结果与黄斑功能以及症状出现与开始大剂量皮质类固醇治疗之间的间隔相关（均P < 0.01）。具有完整COST线的眼睛表现出完整的IS/OS和正常的RPE层以及更好的视觉功能和正常的视网膜敏感性。结论. OCT结果与黄斑功能以及晚期VKH的其他临床结果密切相关。特别是关于COST线和视网膜敏感性，OCT和微视野检查结果可能有助于评估晚期VKH。
Purpose. To characterize the optical coherence tomography (OCT) findings in late-stage Vogt-Koyanagi-Harada (VKH) disease and its correlation with visual function. Methods. The records of patients with late-stage VKH disease (defined as ≥12 months from disease onset) were retrospectively reviewed. The analysis focused on the OCT findings and microperimetry, in addition to the possible correlation between morphology and functional findings. Results. Twenty-nine patients (58 eyes) were included. Mean age at onset was 34.24 ± 10.67 years. The OCT revealed that the outer retina and retinal pigment epithelium (RPE) were mainly affected. These effects included RPE thickening and breakage or disappearance of the cone outer segment tip (COST) line and/or inner segment/outer segment (IS/OS) junction. The COST line and IS/OS results were related to macular function and the interval between symptom onset and initiation of high-dose corticosteroid treatment (all P < 0.01). Eyes with intact COST lines demonstrated intact IS/OS and normal RPE layers as well as better visual function and normal retinal sensitivity. Conclusions. The OCT findings are strongly correlated with macular function, as well as other clinical findings in late-stage VKH. With respect to the COST line and retinal sensitivity especially, the OCT and microperimetry findings may be useful for evaluating later-stage VKH.