Movement-related dynamics of cortical oscillations in Parkinson's disease and essential tremor
Movement-related dynamics of cortical oscillations in Parkinson's disease and essential tremor
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DOI：
10.1093/brain/aww144
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发表时间：
2016-08-01
期刊：
影响因子：
14.5
通讯作者：
Richardson, R. Mark
中科院分区：
文献类型：
--
作者：
Kondylis, Efstathios D.;Randazzo, Michael J.;Richardson, R. Mark
最近的皮质电图数据表明，初级运动皮层的β相与γ -振幅过度耦合，深部脑刺激通过降低基线相位-振幅耦合促进运动改善。然而，运动过程中相幅耦合的动态调节和其他运动障碍（如特发性震颤）的一般皮层神经生理学都相对未被探索。为了阐明这些皮层振荡活动与运动和疾病状态之间的相互作用关系，我们使用硬脑膜下皮质电图记录了在视觉提示、激励的握握任务中手部感觉运动皮层的局部场电位，这些受试者分别患有帕金森病（n = 11）、特发性震颤（n = 9）和无运动障碍（n = 6）。我们证明低频振荡的相位与伽马振荡的振幅的异常耦合不是帕金森病所特有的，但也发生在特发性震颤中，最突出的是α与伽马振荡的耦合。这些组之间的运动运动学没有显著差异，这使我们首次表明，在帕金森病和特发性震颤中，强大的α和β去同步是感觉运动皮层活动的共同特征，帕金森病中发生的高β去同步最大，而特发性震颤中发生的α去同步最大。我们还发现，帕金森病患者和特发性震颤患者在运动过程中皮层相幅解耦的空间范围要比没有运动障碍的受试者大得多。这些发现表明，帕金森病和特发性震颤患者可以通过减少这些疾病特有的过度感觉-运动皮层相幅耦合，产生与无运动障碍患者相似的运动。
Recent electrocorticography data have demonstrated excessive coupling of beta-phase to gamma-amplitude in primary motor cortex and that deep brain stimulation facilitates motor improvement by decreasing baseline phase-amplitude coupling. However, both the dynamic modulation of phase-amplitude coupling during movement and the general cortical neurophysiology of other movement disorders, such as essential tremor, are relatively unexplored. To clarify the relationship of these interactions in cortical oscillatory activity to movement and disease state, we recorded local field potentials from hand sensorimotor cortex using subdural electrocorticography during a visually cued, incentivized handgrip task in subjects with Parkinson's disease (n = 11), with essential tremor (n = 9) and without a movement disorder (n = 6). We demonstrate that abnormal coupling of the phase of low frequency oscillations to the amplitude of gamma oscillations is not specific to Parkinson's disease, but also occurs in essential tremor, most prominently for the coupling of alpha to gamma oscillations. Movement kinematics were not significantly different between these groups, allowing us to show for the first time that robust alpha and beta desynchronization is a shared feature of sensorimotor cortical activity in Parkinson's disease and essential tremor, with the greatest high-beta desynchronization occurring in Parkinson's disease and the greatest alpha desynchronization occurring in essential tremor. We also show that the spatial extent of cortical phase-amplitude decoupling during movement is much greater in subjects with Parkinson's disease and essential tremor than in subjects without a movement disorder. These findings suggest that subjects with Parkinson's disease and essential tremor can produce movements that are kinematically similar to those of subjects without a movement disorder by reducing excess sensorimotor cortical phase-amplitude coupling that is characteristic of these diseases.