Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor
Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor
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DOI：
10.1016/j.bbrc.2005.06.161
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发表时间：
2005-09-02
影响因子：
3.1
通讯作者：
Castellon, R
中科院分区：
文献类型：
--
作者：
Hamdi, HK;Castellon, R
橄榄苦苷是一种来自橄榄树的无毒开环环烯醚萜，是一种强大的抗氧化剂和抗血管生成剂。在这里，我们表明它是一种有效的抗癌化合物，直接破坏细胞和无细胞测定中的肌动蛋白丝。橄榄苦苷以剂量响应方式抑制晚期人类肿瘤细胞系的增殖和迁移。在一个新的管破裂测定。橄榄苦苷不可逆地使癌细胞变圆，阻止其复制、运动和侵袭;这些作用在正常细胞中是可逆的。当口服给药的小鼠发展自发性肿瘤，橄榄苦苷完全消退肿瘤在9 - 12天。当肿瘤在完全消退之前被切除时，它们缺乏凝聚力并且具有易碎的一致性。从这些肿瘤中无法回收活细胞。这些观察结果将橄榄苦苷从无毒的抗氧化剂提升为对肿瘤细胞具有直接作用的有效抗肿瘤剂。我们的数据也可以解释富含橄榄的地中海饮食的癌症保护作用。(c)2005年爱思唯尔公司All rights reserved.
Oleuropein, a non-toxic secoiridoid derived from the olive tree, is a powerful antioxidant and anti-angiogenic agent. Here, we show it to be a potent anti-cancer compound, directly disrupting actin filaments in cells and in a cell-free assay. Oleuropein inhibited the proliferation and migration of advanced-grade human tumor cell lines in a dose-responsive manner. In a novel tube-disruption assay. Oleuropein irreversibly rounded cancer cells, preventing their replication, motility, and invasiveness; these effects were reversible in normal cells. When administered orally to mice that developed spontaneous tumors, Oleuropein completely regressed tumors in 9-12 days. When tumors were resected prior to complete regression, they lacked cohesiveness and had a crumbly consistency. No viable cells could be recovered from these tumors. These observations elevate Oleuropein from a non-toxic antioxidant into a potent anti-tumor agent with direct effects against tumor cells. Our data may also explain the cancer-protective effects of the olive-rich Mediterranean diet. (c) 2005 Elsevier Inc. All rights reserved.