CONGENITAL-ABNORMALITIES IN NEWBORN CALVES AFTER INOCULATION OF PREGNANT COWS WITH AKABANE VIRUS
CONGENITAL-ABNORMALITIES IN NEWBORN CALVES AFTER INOCULATION OF PREGNANT COWS WITH AKABANE VIRUS
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DOI：
10.1128/iai.17.2.338-343.1977
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发表时间：
1977-01-01
影响因子：
3.1
通讯作者：
MATUMOTO, M
中科院分区：
文献类型：
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作者：
KUROGI, H;INABA, Y;MATUMOTO, M
在妊娠62-96天，将赤羽病毒的新鲜分离株静脉接种到11头血清阴性妊娠母牛中。接种后18天屠宰两头奶牛，并检查胎仔;允许剩余奶牛分娩。所有接种的奶牛均出现病毒血症和病毒中和抗体，表明奶牛实际上感染了病毒，但未观察到发热或其他临床异常。病毒进一步感染了胎儿。这通过在屠宰奶牛的2只胎儿中的1只中分离出病毒来证明，并且在2只胎儿中观察到多发性肌炎。7头活产小牛中有6头在其前初乳血清中具有抗赤羽根抗体，表明这些小牛发生了子宫内病毒感染。一些宫内感染的小牛表现出先天性异常，如脑缺陷，积水性无脑畸形和关节弯曲。赤羽病毒显然是牛流行性流产和先天性关节弯曲-积水无脑综合征的病原体。
A fresh isolate of Akabane virus was inoculated i.v. into 11 seronegative pregnant cows at 62-96 days of gestation. Two of the cows were slaughtered 18 days post-inoculation, and the fetuses were examined; the remaining cows were allowed to give birth. All inoculated cows developed viremia and neutralizing antibody for the virus, indicating that the cows were actually infected with the virus, although fever or other clinical abnormalities were not noted. The virus further infected the fetuses. This was proved by virus isolation in 1 of the 2 fetuses from the slaughtered cows, and polymyositis was noted in both fetuses. Six of 7 calves born alive had anti-Akabane antibody in their precolostral sera, indicating that in utero infection with the virus took place in these calves. Some of the in utero-infected calves demonstrated congenital abnormalities such as cerebral defect, hydranencephaly and arthrogryposis. Akabane virus apparently is the etiological agent of epizootic abortion and congenital arthrogryposis-hydranencephaly syndrome in cattle.