A pilot study to assess the impact of naltrexone implant on accidental opiate overdose in 'high-risk' adolescent heroin users
A pilot study to assess the impact of naltrexone implant on accidental opiate overdose in 'high-risk' adolescent heroin users
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DOI：
10.1080/13556210310001602257
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发表时间：
2003-09-01
影响因子：
3.4
通讯作者：
Tait, RJ
中科院分区：
文献类型：
--
作者：
Hulse, GK;Tait, RJ
经常吸食海洛因的人的发病率和死亡率远远高于普通人群。自2000年8月以来，西澳大利亚州根据联邦治疗商品管理局的同情指南，对“高风险”海洛因使用者使用了植入性纳曲酮。这项初步研究比较了8名使用纳曲酮植入治疗前后的青少年的意外阿片类药物过量和其他导致住院表现的发病率。我们回顾了珀斯四家公立医院参与者的医院病历。审查期为1999年9月至2002年10月。这8名青少年(年龄15-19岁)最初在2000年9月至2001年9月期间接受了纳曲酮植入治疗。数据表明，植入纳曲酮后阿片类药物过量治疗显著减少，与口腔植入前相比，口服纳曲酮治疗期间阿片类药物过量减少较小。对高危海洛因使用者的植入治疗可能为预防意外过量阿片类药物相关的死亡提供重要的预防。这些令人鼓舞的发现现在需要在较长时期内使用更大的队列进行验证。
Morbidity and mortality rates for regular heroin users are much greater than those observed in the general population. In 'high-risk' heroin users implantable naltrexone has been used under Commonwealth Therapeutic Goods Administration Compassionate guidelines in Western Australia since August 2000. This pilot study compared the frequeney of accidental opiate overdose and other morbidity resulting in hospital presentations in eight 'high-risk' dependent heroin using adolescents pre- and post-naltrexone implant treatment. We reviewed the hospital medical records retrospectively for the participants across the four public hospitals in Perth. The review period was September 1999-October 2002. The eight adolescents (aged 15 19 years) initially underwent naltrexone implant treatment between September 2000 and September 2001. The data indicated a dramatic reduction in opiate overdose post-implantable naltrexone treatment, with a smaller reduction in opiate overdose during oral naltrexone treatment compared to the pre-orallimplant period. Implant treatment in the high-risk heroin user may provide an important prophylaxis against mortality associated with accidental opiate overdose. These encouraging findings now require validation using a larger cohort over an extended period.