Stimulation of aldosterone secretion by metoclopramide in humans: apparent independence of renal and pituitary mediation.
Stimulation of aldosterone secretion by metoclopramide in humans: apparent independence of renal and pituitary mediation.
复制标题
甲氧氯普胺对人类醛固酮分泌的刺激：肾脏和垂体介导的明显独立性。
DOI：
10.1016/0026-0495(81)90161-x
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Weinberger,MH
中科院分区：
文献类型：
--
作者：
Pratt,JH;Ganguly,A;Parkinson,CA;Weinberger,MH
甲氧氯普胺（MP）是一种多巴胺拮抗剂，其刺激醛固酮分泌的机制尚未明确。我们研究了肾脏或垂体介导MP对醛固酮分泌的影响的潜在作用。在6名无肾和6名肾功能减退患者以及6名正常受试者中测量了对MP静脉给药的反应。MP增加血浆醛固酮浓度（PAC）在正常受试者的方式类似于以前的报道。MP没有增加血浆中的肾素活性（PRA），皮质醇，钾，钠的水平。六个anephric患者（所有这些人都检测不到PRA）MP反应PAC的增加，这些反应的幅度与血浆钾浓度。所有6名低血糖患者在MP给药后均显示PAC增加。MP增加血浆催乳素水平在正常人和anephric患者;一个hypopulmonary患者有较高的基础血浆催乳素水平与MP增加。总之，无论是肾脏还是垂体都不参与MP刺激醛固酮产生的机制。这些观察结果表明，MP可能作用于肾上腺，引起分泌醛固酮。
Metoclopramide (MP), a dopamine antagonist, stimulates secretion of aldosterone by a mechanism which has not been defined. We examined a potential role for either the kidney or the pituitary to mediate MPs effect on aldosterone secretion. Responses to MP administered i.v. were measured in six anephric and six hypopituitary patients as well as in six normal subjects. MP increased the plasma aldosterone concentration (PAC) in normal subjects in a fashion similar to what had previously been reported. MP produced no increase in plasma levels of renin activity (PRA), cortisol, potassium, or sodium. Three of six anephric patients (all of whom had undetectable PRA) responded to MP with increases in PAC; the magnitude of these responses correlated with the plasma potassium concentration. All six hypopituitary patients showed increases in PAC after MP administration. MP increased plasma prolactin levels in normal subjects and anephric patients; one hypopituitary patient had high basal plasma prolactin levels which increased with MP. In conclusion, neither the kidney nor the pituitary is involved in the mechanism for MP stimulated aldosterone production. These observations suggest that MP may act on the adrenal to evoke secretion of aldosterone.