XANTHINE NEPHROPATHY IN A PATIENT WITH LYMPHOSARCOMA TREATED WITH ALLOPURINOL
XANTHINE NEPHROPATHY IN A PATIENT WITH LYMPHOSARCOMA TREATED WITH ALLOPURINOL
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DOI：
10.1056/nejm197008132830708
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发表时间：
1970-01-01
影响因子：
158.5
通讯作者：
LITTLE, AS
中科院分区：
文献类型：
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作者：
BAND, PR;SILVERBERG, DS;LITTLE, AS
别嘌醇是一种被证实具有治疗高尿酸血症和高尿酸尿酸状态的药物。1，2别嘌醇和它的主要代谢产物氧并嘌醇都能抑制黄嘌呤氧化酶，该酶通常将次黄嘌呤转化为黄嘌呤，并将黄嘌呤转化为尿酸。1，在血液系统肿瘤中，尿酸排泄量可能会增加两到四倍。1高尿酸血症和高尿酸尿在抗癌药物或放射治疗后可能会变得更加明显。细胞的快速溶解可导致血尿酸突然升高、高尿酸尿、尿结石形成和尿路梗阻。在这些患者中，一般建议预防性使用别嘌醇。
ALLOPURINOL is an agent of proved value for the treatment of hyperuricemic and hyperuricosuric states.1,2Both allopurinol and its principal metabolic product, oxypurinol, inhibit the enzyme xanthine oxidase that normally converts hypoxanthine to xanthine, and xanthine to uric acid.1,2In hematopoietic cancer uric acid excretions may be increased two to four times.1Hyperuricemia and hyperuricosuria may become even more marked after therapy with anticancer agents or radiation. The rapid lysis of cells can lead to abrupt elevation of serum uric acid, hyperuricosuria, urinary-stone formation and urinary-tract obstruction. In these patients the prophylactic use of allopurinol is generally advised, the drug . . .