Genetic determinants of pathogenesis by feline infectious peritonitis virus
Genetic determinants of pathogenesis by feline infectious peritonitis virus
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DOI：
10.1016/j.vetimm.2011.06.021
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发表时间：
2011-10-15
影响因子：
1.8
通讯作者：
Brown, Meredith A.
中科院分区：
文献类型：
--
作者：
Brown, Meredith A.
猫传染性腹膜炎（FIP）是一种与猫冠状病毒（FCoV）相关的猫致死性、免疫增强性和进行性病毒性疾病。与FIPV发病机制特异相关的病毒遗传决定因子尚未发现。冠状病毒基因组的刺突、非结构蛋白3c和膜中的病毒基因特征已被证明通常与疾病表现相关。“体内突变转变假说”被广泛接受，并假定病毒在体内发生从头突变，从而产生毒力。“不同的循环无毒和强毒株”的存在是病毒发病机制的另一种假设。这两种假说的病毒动力学可能在FIP的发生中起作用。流行病学数据表明，猫的遗传背景有助于FIP的表现。进一步的研究探索FIP疾病的病毒和宿主遗传决定因素，为这种疾病的管理提供了具体的机会。(C)2011 Elsevier B.V.保留所有权利。
Feline infectious peritonitis (FIP) is a fatal, immune-augmented, and progressive viral disease of cats associated with feline coronavirus (FCoV). Viral genetic determinants specifically associated with FIPV pathogenesis have not yet been discovered. Viral gene signatures in the spike, non-structural protein 3c, and membrane of the coronavirus genome have been shown to often correlate with disease manifestation. An "in vivo mutation transition hypothesis" is widely accepted and postulates that de novo virus mutation occurs in vivo giving rise to virulence. The existence of "distinct circulating avirulent and virulent strains" is an alternative hypothesis of viral pathogenesis. It may be possible that viral dynamics from both hypotheses are at play in the occurrence of FIP. Epidemiologic data suggests that the genetic background of the cat contributes to the manifestation of FIP. Further studies exploring both viral and host genetic determinants of disease in FIP offer specific opportunities for the management of this disease. (C) 2011 Elsevier B.V. All rights reserved.