COVID-19 symptoms and SARS-CoV-2 infection among people living with HIV in the US: the MACS/WIHS combined cohort study
COVID-19 symptoms and SARS-CoV-2 infection among people living with HIV in the US: the MACS/WIHS combined cohort study
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DOI：
10.1080/25787489.2020.1844521
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发表时间：
2020-11-18
影响因子：
1.6
通讯作者：
Adimora, Ada A.
中科院分区：
文献类型：
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作者：
D'Souza, Gypsyamber;Springer, Gayle;Adimora, Ada A.
目的了解多中心艾滋病队列研究(MACS)和妇女艾滋病机构间研究(WIHS)参与者新冠肺炎症状和拭子检测情况。方法收集2020年4-6月30日电话调查资料。对症状和检测患病率进行调查。结果3411名参与者完成了调查，其中2078名(61%)PLWH和1333名HIV血清阴性(SN)参与者来自全美。有13%(n=441)的人被检测出SARS-CoV-2感染(PLWH的13.4%对SN的12.2%)。在受试者中，PLWH的阳性率高于SN(11.2%vs6.1%，p=0.08)。没有进行测试的原因包括无法进行测试(30%的参与者)和不知道在哪里进行测试(16%的参与者)。自2020年1月以来报告的大多数PLWH和SN的症状相似，包括头痛(23%对24%)、肌痛(19%对18%)、呼吸短促(14%对13%)、寒战(12%对10%)、发烧(6%对6%)以及味觉或嗅觉丧失(6%对7%)。在SARS-CoV-2DNA检测阳性的PLWH中，最常见的症状是头痛(71%)、肌肉痛(68%)、咳嗽(68%)和寒战(65%)。多因素分析显示，新冠肺炎症状在PLWH和SN中的患病率和类型相似，但PLWH组和SN组之间差异无统计学意义(P>0.046)。SARS-CoV-2感染可能在PLWH中升高。
BackgroundSARS-CoV-2 infection among People Living With HIV (PLWH) is not well-described.ObjectiveTo study COVID-19 symptoms and SARS-CoV-2 PCR-based swab testing among participants of the Multicenter AIDS Cohort Study (MACS) and Women's Interagency HIV Study (WIHS).MethodsA telephone survey was collected April-June 30, 2020. Symptom and testing prevalence were explored. Multivariable logistic regression was used to examine the factors associated with SARS-CoV-2 positivity.ResultsThe survey was completed by 3411 participants, including 2078 (61%) PLWH and 1333 HIV-seronegative (SN) participants from across the US. Thirteen percent (n = 441) were tested for SARS-CoV-2 infection (13.4% of PLWH vs 12.2% of SN). Among those tested, positivity was higher in PLWH than SN (11.2% vs 6.1%, p = 0.08). Reasons for not being tested included testing not being available (30% of participants) and not knowing where to get tested (16% of participants). Most symptoms reported since January 2020 were similar in PLWH and SN, including headache (23% vs. 24%), myalgias (19% vs 18%), shortness of breath (14% vs 13%), chills (12% vs 10%), fever (6% vs 6%) and loss of taste or smell (6% vs 7%). Among PLWH who tested positive for SARS-CoV-2 DNA, the most common symptoms were headache (71%), myalgia (68%), cough (68%) and chills (65%). In multivariable analysis among those tested, the odds of SARS-CoV-2 positivity were higher among PLWH than SN (aOR = 2.22 95%CI = 01.01-4.85, p = 0.046) and among those living with others versus living alone (aOR = 2.95 95%CI = 1.18-7.40).ConclusionPrevalence and type of COVID-19 symptoms were similar in PLWH and SN. SARS-CoV-2 infection may be elevated among PLWH.