Neuropathology of dementia in a large cohort of patients with Parkinson's disease
Neuropathology of dementia in a large cohort of patients with Parkinson's disease
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DOI：
10.1016/j.parkreldis.2013.05.010
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发表时间：
2013-10-01
影响因子：
4.1
通讯作者：
Koevari, Enikoe
中科院分区：
文献类型：
--
作者：
Horvath, Judit;Herrmann, Francois R.;Koevari, Enikoe
本研究的目的是在大规模尸检队列中确定不同的病理聚集体(皮质路易体、神经元tau包涵体和β-淀粉样斑块沉积)在与帕金森病(PD)相关的痴呆中的作用。根据先前发表的指南，对每个病例的总LB评分、神经原纤维缠结(NFT)的Braak分期和Aβ沉积的Thal时相进行评估。与非痴呆PD组相比，痴呆PD组所有这三种病变类型都更丰富，但新皮质LB病理是痴呆的最重要底物。Aβ期的严重程度、NFT分期和皮质LB值之间存在显著的相关性。在一组严重痴呆的帕金森病患者中，皮质tau负荷比该组其他患者高得多。广泛的皮质神经营养不良不可避免地与痴呆症有关。一些患者尽管皮质LB值很高，但认知功能仍然完好无损。总而言之，我们的数据有力地支持了新皮质LBS和tau沉积的组合但不同的作用。(C)2013年提交人。爱思唯尔有限公司出版。保留所有权利。
The aim of our study was to establish the contribution of distinct pathological aggregates (cortical Lewy bodies (LB), neuronal tau-inclusions and beta-amyloid plaque (A beta) deposition) in dementia related to Parkinson's disease (PD) in a large autopsy cohort.We studied the brains of 155 PD patients, 109 of whom were clinically demented. The total LB score, the Braak stages for neurofibrillary tangles (NFT) and the Thal phases for A beta deposition were assessed in each case, according to previously published guidelines.All the three lesion types were more abundant in the demented PD group, compared to the non-demented PD group, but neocortical LB pathology was the most important substrate of dementia. A significant correlation was found between the severity of A beta phases, NFT stages and cortical LB scores. In a subgroup of severely demented PD patients, cortical tau burden was much higher than in the rest of the group. Extensive cortical NFTs associate unavoidably with dementia. Some patients remain cognitively intact despite high cortical LB score. In conclusion, our data strongly support a combining, yet distinct role of neocortical LBs and tau deposits. (c) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.