Hemidesmosomes and focal contact proteins: functions and cross-talk in keratinocytes, bullous diseases and wound healing.
Hemidesmosomes and focal contact proteins: functions and cross-talk in keratinocytes, bullous diseases and wound healing.
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DOI：
10.1016/j.jdermsci.2011.01.005
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发表时间：
2011-04
影响因子：
4.6
通讯作者：
Jones JC
中科院分区：
文献类型：
--
作者：
Tsuruta D;Hashimoto T;Hamill KJ;Jones JC
皮肤的最外层，即表皮，通过一层称为基底膜区 (BMZ) 的细胞外基质蛋白附着在真皮上。在完整的皮肤中，表皮基底层中的角质形成细胞与BMZ的粘附主要是通过与角蛋白细胞骨架结合的半桥粒促进的。培养的角质形成细胞不会组装真正的半桥粒，尽管沿着细胞的基底附着表面和朝向重新填充划痕伤口的角质形成细胞的前缘发现了半桥粒蛋白簇（稳定的锚定接触）。被称为焦点接触的肌动蛋白细胞骨架相关基质粘附装置不被认为在完整皮肤中角质形成细胞与BMZ的粘附中发挥重要作用，但在培养的角质形成细胞中很突出，据信它们调节细胞迁移。我们回顾了半桥粒的分子成分、功能、动力学和串扰以及角质形成细胞中的焦点接触。此外，我们还简要描述了它们在自身免疫性和遗传性皮肤水疱性疾病中的作用。我们还讨论了最近的出版物，与预期相反，这些出版物表明某些焦点接触蛋白阻碍角质形成细胞迁移，而半桥粒蛋白在伤口愈合过程中调节定向角质形成细胞运动。
The outer most layer of the skin, the epidermis, is attached to the dermis via a sheet of extracellular matrix proteins termed the basement membrane zone (BMZ). In the intact skin, adhesion of the keratinocytes in the basal layer of the epidermis to the BMZ is facilitated primarily by hemidesmosomes which associate with the keratin cytoskeleton. Cultured keratinocytes do not assemble bona fide hemidesmosomes although hemidesmosome protein clusters (stable anchoring contacts) are found along the substrate-attached surface of the cells and towards the leading edge of keratinocytes repopulating scratch wounds. Actin cytoskeleton-associated matrix adhesion devices termed focal contacts are not thought to play an important role in the adhesion of keratinocytes to the BMZ in intact skin but are prominent in cultured keratinocytes where they are believed to regulate cell migration. We review the molecular components, functions, dynamics and cross-talk of hemidesmosomes and focal contacts in keratinocytes. In addition, we briefly describe what is known about their role in autoimmune and genetic blistering diseases of the skin. We also discuss recent publications which indicate, contrary to expectation, that certain focal contact proteins retard keratinocyte migration while hemidesmosomal proteins regulate directed keratinocyte motility during wound healing.
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影响因子：
20.3
作者：
Crew, VK;Burton, N;Anstee, DJ
通讯作者：
Anstee, DJ
整联蛋白α3β1在局灶性粘连中的不同功能和α6β4/bullous子型抗原抗原在新的稳定锚定接触（SAC）的角质形成细胞中：与Hemidesmosmosys的关系。
影响因子：
7.8
作者：
Carter, W G;Kaur, P;Gil, S G;Gahr, P J;Wayner, E A
通讯作者：
Wayner, E A
影响因子：
21.3
作者：
Gohla, A;Birkenfeld, J;Bokoch, GM
通讯作者：
Bokoch, GM
影响因子：
--
作者：
deHart, GW;Jones, JCR
通讯作者：
Jones, JCR
影响因子：
4.8
作者：
Gonzalez AM;Bhattacharya R;deHart GW;Jones JC
通讯作者：
Jones JC