Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies
Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies
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DOI：
10.1007/s10856-005-5954-2
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发表时间：
2005-02-01
影响因子：
3.7
通讯作者：
Wang, HJ
中科院分区：
文献类型：
--
作者：
Tsou, TL;Tang, ST;Wang, HJ
通过紫外线辐射技术开发出一种具有长期药物扩散功效的改进伤口敷料。它涉及将浓度为0.5-2.0%（w/v）的环丙沙星（CIP）加入到2-羟基甲基丙烯酸酯（HEMA）单体、安息香异丁醚（BIE）引发剂和不同含量的二甲基丙烯酸乙二醇酯（EGDMA）交联剂的水混合物中。增加EGDMA的浓度会降低pHEMA中CIP的释放率。当EGDMA添加量从1%增加到8%时，T-1/2从2.64小时增加到45.67小时。在0≤F≤0.6范围内，1%CIP-pHEMA膜的n值从0.48提高到0.81。这表明药物释放机制介于Fickian扩散模型和Case 11扩散模型之间。采用体外药物动力学琼脂平板法评价浸入膜的药物的抗菌活性。较高浓度的 EGDMA（高达交联剂的 8%）可延长药物释放。与药物浸泡膜相比，新合成的 1% CIP-pHEMA 膜（与 4% EGDMA 交联）可持续释放所包埋的药物，并保持抗菌活性长达 12 天。 (C\)2005 年施普林格科学 + 商业媒体公司
An improved wound dressing with a long-term drug diffusion-efficacy has been developed by UV-radiation technique. It involves incorporation of ciprofloxacin (CIP), at the concentration of 0.5-2.0% (w/v), into a water mixture of 2-hydroxymethacrylate (HEMA) monomer, benzoin isobutyl ether (BIE) initiator and different content of ethylene glycol dimethacrylate (EGDMA) cross-linker. Increasing the concentration of EGDMA would reduce the releasing ratio of CIP from pHEMA. T-1/2 is increased from 2.64 to 45.67 h when the EGDMA is added from 1 to 8%. In the ranges of 0 less than or equal to F less than or equal to 0.6, the n value of 1%CIP-pHEMA membranes is increased from 0.48 to 0.81. It indicates that the mechanism of drug release falls between the Fickian and Case 11 diffusion model. The antibacterial activity of the drug impregnated into the membrane was evaluated by in vitro drug kinetic agar plate method. Higher concentration of EGDMA, up to 8% of the cross-linker, extends the drug release. Comparison with the drug-soaked membranes, the newly synthesized 1% CIP-pHEMA membrane (cross-linked with 4% EGDMA) sustains the release of the entrapped drug and maintains the antibacterial activity up to 12 days. (C\) 2005 Springer Science + Business Media, Inc.