Influence of surfactant and oil composition on the stability and antibacterial activity of eugenol nanoemulsions
Influence of surfactant and oil composition on the stability and antibacterial activity of eugenol nanoemulsions
复制标题
表面活性剂和油脂组成对丁香酚纳米乳稳定性和抗菌活性的影响
DOI：
10.1016/j.lwt.2015.01.012
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发表时间：
2015-06-01
影响因子：
6
通讯作者：
Li, Yan
中科院分区：
文献类型：
--
作者：
Li, Wei;Chen, Huanle;Li, Yan
采用高压均质法制备了丁香酚（Eu）纳米乳。并对其稳定性和抑菌活性进行了评价。动态光散射结果表明，十二烷基硫酸钠（SDS）稳定的铕乳液稳定性比吐温80（T80）差。豆油（BO）对乳状液稳定性的改善取决于界面活性剂。对于SDS稳定的乳液，随着BO用量的增加，Eu乳液变得稳定。对于T80稳定的乳液，Eu乳液稳定性的改善明显不同于所报道的。随着BO含量的增加，Eu乳液先稳定，再不稳定，最后稳定。当BO含量为60wt%时，Eu乳液出现重复不稳定性。抑菌活性测试结果表明，乳液包埋可以保护甚至增强Eu的抑菌活性。表面活性剂的种类对铕乳液的抗菌性能有影响，阴离子表面活性剂>非离子表面活性剂。时间杀菌实验表明，Eu T80乳剂中BO含量越低，对大肠杆菌的抑菌效果越好。Coll.（C）2015 Elsevier Ltd.保留所有权利。
Eugenol (Eu) nanoemulsions were prepared by high-pressure homogenization with two surfactants and varied oil compositions. Their stability and antibacterial activities were further evaluated. The results from dynamic light scattering demonstrated that the stability of bulk Eu emulsions stabilized by sodium dodecylsulfate (SDS) was worse than that by Tween 80 (T80). The improvement of emulsion stability by addition of bean oil (BO) depended on the interfacial surfactants. For SDS-stabilized emulsions, Eu emulsions would become stable with the increasing amount of BO. For T80-stabilized emulsions, the improvement of Eu emulsion stability was noticeably different as reported. With the increment of BO, Eu emulsions became stable first, then unstable and finally stable. The repeat instability occurred in Eu emulsions at 60 wt% BO. The results of antibacterial activity showed that emulsion encapsulation could protect and even enhance the antibacterial activity of Eu. The antibacterial capacity of Eu emulsions was affected by the surfactant type, listed as anionic > nonionic surfactant. Time-kill assay presented that lower BO content in Eu-T80 emulsions, the better effect was obtained on the bacterial inhibition against E. coll. (C) 2015 Elsevier Ltd. All rights reserved.