Biology of tumor progression in human melanocytes.
Biology of tumor progression in human melanocytes.
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发表时间：
1987-05
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通讯作者：
M. Herlyn;W. Clark;U. Rodeck;M. Mancianti;J. Jambrosic;H. Koprowski
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作者：
M. Herlyn;W. Clark;U. Rodeck;M. Mancianti;J. Jambrosic;H. Koprowski
人类黑素细胞系统中的肿瘤进展可以被描绘成6个连续阶段。前三个步骤代表非恶性黑素细胞病变，从结构正常的黑素细胞局部增殖到结构和细胞学异常的病变。原发性黑色素瘤可分为无转移能力的径向生长期和有转移能力的垂直生长期。从正常皮肤、非恶性色素性病变和黑色素瘤中分离并维持培养的黑素细胞具有肿瘤进展的每个阶段的特征。细胞遗传学研究揭示了晚期黑色素瘤的非随机染色体异常，涉及染色体1、6和7。组织培养技术的最新进展允许研究正常和恶性细胞的生长调节。六种生长因子受体-生长因子系统似乎在黑素细胞系统中具有生物学意义：EGF、NGF、FGF、PDGF、胰岛素和β-TGF。单克隆抗体已经表征了肿瘤进展的各个阶段的黑素细胞上的大量抗原，使得黑色素瘤成为最广泛研究的人类肿瘤系统之一。
Tumor progression in the human melanocyte system can be delineated into 6 sequential stages. The first three steps represent nonmalignant melanocyte lesions from focal proliferations of structurally normal melanocytes to lesions with architectural and cytologic atypia. Primary melanoma may be divided into radial growth phase without competence for metastasis and vertical growth phase with metastatic competence. Melanocytes isolated from normal skin, nonmalignant pigmented lesions, and melanomas and maintained in culture have properties that are characteristic for each stage of tumor progression. Cytogenetic studies revealed nonrandom chromosomal abnormalities of advanced melanomas involving chromosomes 1, 6, and 7. Recent progress in tissue culture techniques has allowed studies of growth regulation of normal and malignant cells. Six growth factor receptor-growth factor systems seem to be of biologic significance in the melanocyte system: EGF, NGF, FGF, PDGF, insulin, and beta-TGF. Monoclonal antibodies have characterized a large number of antigens on melanocytes of the various stages of tumor progression, making melanoma one of the most widely studied human tumor systems.