SUVmax in FDG-PET at the biopsy site correlates with the proliferation potential of tumor cells in non-Hodgkin lymphoma
SUVmax in FDG-PET at the biopsy site correlates with the proliferation potential of tumor cells in non-Hodgkin lymphoma
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DOI：
10.3109/10428190903440953
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发表时间：
2010-02-01
影响因子：
2.6
通讯作者：
Ishigatsubo, Yoshiaki
中科院分区：
文献类型：
--
作者：
Watanabe, Reina;Tomita, Naoto;Ishigatsubo, Yoshiaki
18F-FDG-PET全身最大标准摄取值（SUVmax）反映了非霍奇金淋巴瘤（NHL）的侵袭性。为了阐明SUVmax在活检部位和肿瘤细胞的增殖潜力之间的相关性，我们研究了36例未经治疗的NHL和5例未经治疗的霍奇金淋巴瘤（HL）通过测量Ki-67增殖指数（MIB-1标记指数）活检标本。测量的MIB-1标记指数分为7个水平：接近0%、5- 20%、21- 40%、41- 60%、61- 80%、81- 95%和接近100%。对24个淋巴结（LN）和17个结节（EN）部位进行了活检。回顾性诊断为8例惰性淋巴瘤，2例套细胞淋巴瘤，26例侵袭性淋巴瘤和5例HL。36例NHL患者活检部位SUVmax与MIB-1标记指数呈正相关（r = 0.69，p < 0.001）。IN组（r = 0.60，p = 0.006）和EN组（r = 0.87，p < 0.001）也观察到相关性。在5例HI患者中，MIB-1标记指数几乎100%一致。在NHL的情况下，SUVmax与增殖潜力相关。
The maximum standard uptake value (SUVmax) of the whole body on 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) reflects the tumor aggressiveness in non-Hodgkin lymphoma (NHL). To clarify the correlation between SUVmax at the biopsy site and the proliferation potential of tumor cells, we studied 36 patients with untreated NHL and five with untreated Hodgkin lymphoma (HL) by measuring the Ki-67 proliferation index (MIB-1 labeling index) in biopsy specimens. The measured MIB-1 labeling index was categorized into seven levels: nearly 0%, 5-20%, 21-40%, 41-60%, 61-80%, 81-95%, and nearly 100%. Twenty-four lymph nodes (LNs) and 17 extranodal (EN) sites were biopsied. The reviewed diagnosis was eight indolent lymphomas, two mantle-cell lymphomas, 26 aggressive lymphomas, and five HLs. A positive correlation was observed between the SUVmax at the biopsy site and the MIB-1 labeling index in the 36 patients with NHL (r = 0.69, p < 0.001). The correlations were also observed in IN group (r = 0.60, p = 0.006) and EN group (r = 0.87, p < 0.001), respectively. In the five patients with HI, the MIB-1 labeling index was uniformly categorized in nearly 100%. The SUVmax correlates with the proliferation potential in the case of NHL.