Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years
Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years
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DOI：
10.2147/cia.s107881
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发表时间：
2016-01-01
影响因子：
3.6
通讯作者：
Fatani, Hanadi
中科院分区：
文献类型：
--
作者：
AL-Qahtani, Khalid Hussain;Tunio, Mutahir A.;Fatani, Hanadi
简介：本研究的目的是评估60岁以上沙特患者分化型甲状腺癌的治疗结果。材料和方法：对252例46-60岁（A组）和118例60岁以上（B组）行甲状腺切除术、放射性碘-131、以及2000年7月至2012年12月期间的促甲状腺激素抑制治疗。不同的临床病理特征，治疗，并发症，无病生存，和总生存率进行了compared.Results：在A组患者的平均年龄为51.9岁（范围：46-60），和那些在组B的平均年龄为68.6岁（范围：62-97）。B组患者有较高的阳性淋巴结（43.2%），P=0.011。B组甲状腺外侵犯、多灶性和淋巴血管间隙侵犯的发生率高于A组。术后并发症（永久性甲状旁腺功能减退、出血和伤口感染）在B组中也更多（分别为P=0.043、P=0.011和P=0.021）。B组患者的局部复发率更高（11.0%，P=0.025）;同样，B组的远处转移率更高（15.3%，P=0.003）。10年无瘤生存率A组为87.6%，B组为70.8%（P
Introduction: The aim of this study was to evaluate the treatment outcomes of differentiated thyroid cancer in Saudi patients aged above 60 years.Materials and methods: Comparative analysis was performed in 252 patients aged 46-60 years (Group A) and 118 patients aged above 60 years (Group B), who had thyroidectomy, radioactive iodine-131, and thyroid-stimulating hormone suppression therapy between July 2000 and December 2012. Different clinicopathological features, treatment, complications, disease-free survival, and overall survival rates were compared.Results: Mean age of patients in Group A was 51.9 years (range: 46-60), and mean age of those in Group B was 68.6 years (range: 62-97). Group B patients had higher positive lymph nodes (43.2%), P=0.011. The frequency of extrathyroidal extension, multifocality, and lymphovascular space invasion was seen more in Group B than in Group A. Postsurgical complications (permanent hypoparathyroidism, bleeding, and wound infections) were also seen more in Group B (P=0.043, P=0.011, and P=0.021, respectively). Group B patients experienced more locoregional recurrences (11.0%, P=0.025); similarly, more distant metastases were observed in Group B (15.3%, P=0.003). The 10-year disease-free survival rates were 87.6% in Group A and 70.8% in Group B (P