Plasma homocysteine, vitamin B12 and folate levels in age-related macular degeneration
Plasma homocysteine, vitamin B12 and folate levels in age-related macular degeneration
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DOI：
10.1007/s00417-005-0108-2
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发表时间：
2006-05-01
影响因子：
2.7
通讯作者：
Eldem, Bora
中科院分区：
文献类型：
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作者：
Kamburoglu, Gunhal;Gumus, Koray;Eldem, Bora
本研究的目的是探讨年龄相关性黄斑变性（AMD）与血浆同型半胱氨酸、维生素B12和叶酸水平的关系。将30例渗出型AMD和30例干性AMD患者空腹8小时后的血浆同型半胱氨酸、维生素B12和叶酸水平与30例年龄和性别匹配的健康受试者的结果进行比较，渗出型和干性AMD患者的血浆同型半胱氨酸水平均显著高于对照组，（平均值分别为14.19 +/- 3.11 μ mol/l; 13.07 +/- 2.90 μ mol/l）与对照组（平均值分别为10.79 +/- 2.56 μ mol/l;（p=0.000和p=0.008）相比。与干性AMD组相比，渗出性AMD组的同型半胱氨酸水平较高，但差异无统计学意义（p=0.290）。发现渗出性AMD组的血浆维生素B12水平（289.14 +/- 113.44 pg/l）显著低于对照组（436.17 +/- 204.12 pg/l）和干性AMD组（443.47 +/- 190.83 pg/l;（p=0.000）。血浆叶酸水平在各组之间具有可比性（p=0.106）。这项研究表明，血浆同型半胱氨酸升高与AMD之间存在关联，无论其亚型如何。需要进一步的前瞻性对照研究来调查同型半胱氨酸在AMD中的可能作用以及维生素B12和叶酸补充剂在此过程中的作用。
The purpose of this study was to investigate the association of age-related macular degeneration (AMD) with plasma homocysteine, vitamin B12, and folate levels.Sixty patients diagnosed with AMD at our clinic between March 2004 and September 2004 were assessed in a prospective cross-sectional study. Plasma homocysteine, vitamin B12, and folate levels taken after 8 h of fasting from 30 patients with exudative AMD and 30 patients with dry AMD were compared with the results of 30 age- and sex-matched healthy participants.Patients with both exudative and dry types of AMD had significantly higher plasma homocysteine levels (mean 14.19 +/- 3.11 mu mol/l; 13.07 +/- 2.90 mu mol/l respectively) compared with the controls (mean 10.79 +/- 2.56 mu mol/l; (p=0.000 and p=0.008 respectively). Homocysteine levels were higher in the exudative AMD group compared with the dry AMD group, but the difference was not statistically significant (p=0.290). Plasma vitamin B12 levels were found to be significantly lower in the exudative AMD group (289.14 +/- 113.44 pg/l) compared with the controls (436.17 +/- 204.12 pg/l) and dry AMD group (443.47 +/- 190.83 pg/l; (p=0.000). Plasma folate levels were comparable among groups (p=0.106).This study suggests an association between elevated plasma homocysteine and AMD regardless of the subtype. Further controlled prospective studies are needed to investigate the possible role of homocysteine in AMD and the effect of vitamin B12 and folate supplementation in this process.