Reflex vasodilatation in the cat lip elicited by stimulation of nasal mucosa by chemical irritants.
Reflex vasodilatation in the cat lip elicited by stimulation of nasal mucosa by chemical irritants.
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化学刺激物刺激鼻粘膜引起猫唇反射性血管舒张。
DOI：
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发表时间：
1993
影响因子：
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通讯作者：
K. Karita
中科院分区：
文献类型：
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作者：
Hiroshi Izumi;K. Karita
向鼻粘膜局部施用辣椒素（阈值剂量 150 µM）或尼古丁（阈值剂量 15 mM）以及对鼻粘膜进行电刺激（阈值强度 10 V），会引起麻醉猫同侧下唇的剂量或强度依赖性血流增加。将 3 mM 辣椒素局部应用于鼻粘膜进行预处理，可消除或减少对辣椒素、尼古丁和氨蒸气的反应，但不会对鼻粘膜的光机械或电刺激产生反应。通过用六甲铵（一种自主神经节阻滞剂）进行预处理，大大减少了所有上述刺激引起的血流量增加。这些结果表明，通过化学（辣椒素、尼古丁、氨）、机械或电方法刺激鼻粘膜会引起猫下唇的自主反射性血管舒张。此外，猫的鼻粘膜中似乎至少存在两种类型的传入纤维：一种是辣椒素敏感纤维，而另一种是参与反射性血管舒张的辣椒素抗性纤维。
Local application of capsaicin (threshold dose 150 microM) or nicotine (threshold dose 15 mM) to the nasal mucosa as well as electrical stimulation (threshold intensity 10 V) of the nasal mucosa elicited dose- or intensity-dependent blood flow increases in the ipsilateral lower lips of the anesthetized cats. Pretreatment with 3 mM capsaicin applied locally to the nasal mucosa abolished or reduced the vasodilation in response to capsaicin, nicotine, and ammonia vapor but not to light mechanical or electrical stimulation of the nasal mucosa. The blood flow increases elicited by all above stimuli were greatly reduced by pretreatment with hexamethonium, an autonomic ganglion blocker. These results suggest that stimulation of the nasal mucosa by chemical (capsaicin, nicotine, ammonia), mechanical, or electrical methods elicits the autonomic reflex vasodilatation in the cat lower lips. Furthermore, there seem to be at least two types of afferent fibers in the nasal mucosa of the cats: one type is capsaicin-sensitive fibers, while another type is capsaicin-resistant fibers involved in reflex vasodilatation.