ACTION OF VITAMIN D AND PARATHYROID HORMONE IN VITRO ON CALCIUM UPTAKE AND RELEASE BY KIDNEY MITOCHONDRIA
ACTION OF VITAMIN D AND PARATHYROID HORMONE IN VITRO ON CALCIUM UPTAKE AND RELEASE BY KIDNEY MITOCHONDRIA
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DOI：
10.1073/pnas.48.9.1604
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发表时间：
1962-01-01
影响因子：
11.1
通讯作者：
RASMUSSEN, H
中科院分区：
文献类型：
--
作者：
DELUCA, HF;ENGSTROM, GW;RASMUSSEN, H
Isolated rat kidney mitochondria bind calcium by a process which is dependent upon Mg++, adenosine triphosphate (ATP), and oxidizable substrate but which requires neither vitamin D nor parathyroid hormone. The subsequent release of the Ca is stimulated by both vitamin D and parathyroid hormone added in vitro but not by related sterols or other peptide hormones. This effect of parathyroid hormone could be demonstrated only in the presence of vitamin D, whereas the action of the vitamin does not require the presence of hormone. The relationship of these results to the general problem of Ca transport is discussed.
