Relationship between CD4 Regulatory T Cells and Anergy In Vivo.
Relationship between CD4 Regulatory T Cells and Anergy In Vivo.
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DOI：
10.4049/jimmunol.1602031
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发表时间：
2017-04-01
期刊：
影响因子：
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通讯作者：
Mueller DL
中科院分区：
文献类型：
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作者：
Kalekar LA;Mueller DL
效应CD4+ T细胞功能的选择性抑制对于防止免疫细胞介导的对健康组织的损伤是必要的。这在怀孕期间或易患自身免疫的个体中尤其如此。Foxp3+调节性T（Treg）细胞和诱导无反应性（Foxp3−细胞中T细胞功能无反应性的获得性状态）都被认为是抑制对组织限制性自身抗原的危险免疫反应的机制。无反应性CD4+ T细胞和Treg细胞共享许多表型和机制特征，包括CD73和叶酸受体4（FR 4）的表达，以及Treg细胞标记基因的表观遗传修饰，最近出现了这两个子集之间的有趣关系。本文将对这两个亚群进行比较，并探讨无反应性在外周血Treg细胞生成中的作用。
Selective suppression of effector CD4+ T cell functions is necessary to prevent immune cell-mediated damage to healthy tissues. This appears especially true during pregnancy or in individuals predisposed to autoimmunity. Foxp3+ regulatory T (Treg) cells and induction of anergy, an acquired state of T cell functional unresponsiveness in Foxp3− cells, have both been implicated as mechanisms to suppress dangerous immune responses to tissue-restricted self antigens. Anergic CD4+ T cells and Treg cells share a number of phenotypic and mechanistic traits—including the expression of CD73 and folate receptor 4 (FR4), and the epigenetic modification of Treg cell signature genes—and an interesting relationship between these two subsets has recently emerged. In this review, we will compare and contrast these two subsets as well as explore the role of anergy in the generation of peripheral Treg cells.