AMIODARONE AND THYROID HORMONE ACTION JAYNE A.
AMIODARONE AND THYROID HORMONE ACTION JAYNE A.
复制标题
胺碘酮和甲状腺激素的作用 Jayne A.
作者：
J. Franklyn;J. Davis;M. Gammage;W. Littler;D. Ramsden;M. Sheppard
在接受长期胺碘酮治疗的临床甲状腺功能正常受试者中，游离甲状腺素（T4）浓度升高，游离三碘甲状腺原氨酸（T3）水平降低。治疗组的反向 T3 也显着增加。这些变化与抑制 T4 外周脱碘和逆转 T3 一致。尽管 T4 升高，血清促甲状腺激素 (TSH) 水平仍升高，表明胺碘酮对垂体前叶有影响。为了研究胺碘酮与甲状腺激素细胞作用的相互作用，我们在体外检查了该药物对 T3 与从大鼠垂体前叶组织制备的分离细胞核结合的影响。胺碘酮以剂量依赖性方式抑制 T3 的核结合。体外添加胺碘酮也刺激培养的大鼠垂体前叶细胞释放 TSH，这与 T3 拮抗作用一致。这些研究提供了胺碘酮通过核 T3 受体结合介导对促甲状腺激素细胞产生直接影响的证据。
In clinically euthyroid subjects on long‐term amiodarone therapy free thyroxine (T4) concentrations were increased and free triiodothyronine (T3) levels reduced. There was also a marked increase in reverse T3 in the treated group. These changes are consistent with inhibition of peripheral deiodination of T4 and reverse T3. Despite the rise in T4 serum thyrotrophin (TSH) levels were increased, suggesting an effect of amiodarone on the anterior pituitary. To investigate the interaction of amiodarone with the cellular actions of thyroid hormones we examined the influence of the drug in vitro on the binding of T3 to isolated nuclei prepared from rat anterior pituitary tissue. Amiodarone inhibited the nuclear binding of T3 in a dose dependent fashion. Addition of amiodarone in vitro also stimulated TSH release from cultured rat anterior pituitary cells, consistent with a T3 antagonistic effect. These studies provide evidence for a direct influence of amiodarone on the thyrotroph, mediated via nuclear T3 receptor binding.
胺碘酮对大鼠血清甲状腺激素和肝甲状腺素 5-单碘化的影响。
影响因子：
4.8
作者：
Sogol,PB;Hershman,JM;Reed,AW;Dillmann,WH
通讯作者：
Dillmann,WH